Unwrapping the unappreciated

recent progress in Remak Schwann cell biology

Breanne L. Harty, Kelly Monk

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Schwann cells (SCs) are specialized glial cells that myelinate and protect axons in the peripheral nervous system (PNS). Although myelinating SCs are more commonly studied, the PNS also contains a variety of non-myelinating SCs, including but not limited to Remak SCs (RSCs), terminal SCs, enteric glia. Although the field currently lacks many robust tools for interrogating the functions of non-myelinating SCs, recent evidence suggests that, like their myelinating counterparts, non-myelinating SCs are critical for proper PNS function. In this review, we focus specifically on RSCs and highlight recent advances in understanding regulators of RSC development, function, and participation in PNS regeneration.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalCurrent Opinion in Neurobiology
Volume47
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Schwann Cells
Cell Biology
Peripheral Nervous System
Neuroglia
Axons
Regeneration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Unwrapping the unappreciated : recent progress in Remak Schwann cell biology. / Harty, Breanne L.; Monk, Kelly.

In: Current Opinion in Neurobiology, Vol. 47, 01.12.2017, p. 131-137.

Research output: Contribution to journalReview article

@article{e035c31b78114af69776245fccdb6ba3,
title = "Unwrapping the unappreciated: recent progress in Remak Schwann cell biology",
abstract = "Schwann cells (SCs) are specialized glial cells that myelinate and protect axons in the peripheral nervous system (PNS). Although myelinating SCs are more commonly studied, the PNS also contains a variety of non-myelinating SCs, including but not limited to Remak SCs (RSCs), terminal SCs, enteric glia. Although the field currently lacks many robust tools for interrogating the functions of non-myelinating SCs, recent evidence suggests that, like their myelinating counterparts, non-myelinating SCs are critical for proper PNS function. In this review, we focus specifically on RSCs and highlight recent advances in understanding regulators of RSC development, function, and participation in PNS regeneration.",
author = "Harty, {Breanne L.} and Kelly Monk",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.conb.2017.10.003",
language = "English (US)",
volume = "47",
pages = "131--137",
journal = "Current Opinion in Neurobiology",
issn = "0959-4388",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Unwrapping the unappreciated

T2 - recent progress in Remak Schwann cell biology

AU - Harty, Breanne L.

AU - Monk, Kelly

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Schwann cells (SCs) are specialized glial cells that myelinate and protect axons in the peripheral nervous system (PNS). Although myelinating SCs are more commonly studied, the PNS also contains a variety of non-myelinating SCs, including but not limited to Remak SCs (RSCs), terminal SCs, enteric glia. Although the field currently lacks many robust tools for interrogating the functions of non-myelinating SCs, recent evidence suggests that, like their myelinating counterparts, non-myelinating SCs are critical for proper PNS function. In this review, we focus specifically on RSCs and highlight recent advances in understanding regulators of RSC development, function, and participation in PNS regeneration.

AB - Schwann cells (SCs) are specialized glial cells that myelinate and protect axons in the peripheral nervous system (PNS). Although myelinating SCs are more commonly studied, the PNS also contains a variety of non-myelinating SCs, including but not limited to Remak SCs (RSCs), terminal SCs, enteric glia. Although the field currently lacks many robust tools for interrogating the functions of non-myelinating SCs, recent evidence suggests that, like their myelinating counterparts, non-myelinating SCs are critical for proper PNS function. In this review, we focus specifically on RSCs and highlight recent advances in understanding regulators of RSC development, function, and participation in PNS regeneration.

UR - http://www.scopus.com/inward/record.url?scp=85032302899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032302899&partnerID=8YFLogxK

U2 - 10.1016/j.conb.2017.10.003

DO - 10.1016/j.conb.2017.10.003

M3 - Review article

VL - 47

SP - 131

EP - 137

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

ER -