Abstract
A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 455-458 |
| Number of pages | 4 |
| Journal | Archives of Ophthalmology |
| Volume | 91 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Unusual Ocular Involvement in Acute Disseminated Histiocytosis X. / Lahav, Moshe; Albert, Daniel.
In: Archives of Ophthalmology, Vol. 91, No. 6, 01.01.1974, p. 455-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unusual Ocular Involvement in Acute Disseminated Histiocytosis X
AU - Lahav, Moshe
AU - Albert, Daniel
PY - 1974/1/1
Y1 - 1974/1/1
N2 - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.
AB - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.
UR - http://www.scopus.com/inward/record.url?scp=0016227893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016227893&partnerID=8YFLogxK
U2 - 10.1001/archopht.1974.03900060469008
DO - 10.1001/archopht.1974.03900060469008
M3 - Article
C2 - 4827431
AN - SCOPUS:0016227893
VL - 91
SP - 455
EP - 458
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 6
ER -