Unusual Ocular Involvement in Acute Disseminated Histiocytosis X

Moshe Lahav, Daniel Albert

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.

Original languageEnglish (US)
Pages (from-to)455-458
Number of pages4
JournalArchives of Ophthalmology
Volume91
Issue number6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

Fingerprint

Iris
Mydriatics
Meninges
Histiocytes
Choroid
Pupil
Optic Nerve
Secondary Prevention
Dilatation
Parturition
Skin
Familial Letterer-Siwe disease
Brain

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Unusual Ocular Involvement in Acute Disseminated Histiocytosis X. / Lahav, Moshe; Albert, Daniel.

In: Archives of Ophthalmology, Vol. 91, No. 6, 01.01.1974, p. 455-458.

Research output: Contribution to journalArticle

@article{05b8c8c283db4711a90e91bef2eb250f,
title = "Unusual Ocular Involvement in Acute Disseminated Histiocytosis X",
abstract = "A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.",
author = "Moshe Lahav and Daniel Albert",
year = "1974",
month = "1",
day = "1",
doi = "10.1001/archopht.1974.03900060469008",
language = "English (US)",
volume = "91",
pages = "455--458",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Unusual Ocular Involvement in Acute Disseminated Histiocytosis X

AU - Lahav, Moshe

AU - Albert, Daniel

PY - 1974/1/1

Y1 - 1974/1/1

N2 - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.

AB - A white infant was born with acute disseminated histiocytosis X. Clinical ocular examination at birth revealed thickening of the irides with a nodular lesion of the right iris and a focal linear discoloration of the left iris. The pupils showed minimal dilatation following instillation of mydriatics. The child died at 7 days of age; histopathologic examination revealed massive infiltration of histiocytes in the iris, choroid, and meninges of the optic nerve. This pattern of ocular involvement is rare in acute disseminated histiocytosis X. There was involvement by similar cells of the skin, visceral organs, and brain. This association of anterior uveal involvement with severe though clinically unrecognized visceral involvement has been described previously, but not emphasized. Recognition of the ocular involvement may be helpful in the diagnosis, and contribute to the early institution of therapy.

UR - http://www.scopus.com/inward/record.url?scp=0016227893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016227893&partnerID=8YFLogxK

U2 - 10.1001/archopht.1974.03900060469008

DO - 10.1001/archopht.1974.03900060469008

M3 - Article

C2 - 4827431

AN - SCOPUS:0016227893

VL - 91

SP - 455

EP - 458

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 6

ER -