Unusual fallopian tube neoplasm in a 10-year-old patient with Proteus syndrome: A case report and review of the literature

Tracy Funk, Patty Frew, William Rodgers, Megan Troxell

Research output: Contribution to journalReview article

1 Scopus citations


We report a case of fallopian tube and peritoneal lesions resected from a 10-year-old girl with Proteus syndrome. The papillary fallopian tube tumor expressed CA-125 and demonstrated negative staining for CEA, CD 15, calretinin, and CK 5/6. Nondilated portions of fallopian tube exhibited evidence of an in situ component. This patient was also found to have peritoneal mesothelial hyperplasia as well as cystic peritoneal lesions of mesothelial origin, with positive calretinin staining. This case provides direct evidence of both Müllerian and mesothelial lesions arising concurrently in a patient with Proteus syndrome and represents the 1st documented fallopian tube neoplasm. Previously reported lesions involving the female and male genital tracts in patients with Proteus syndrome are reviewed.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalPediatric and Developmental Pathology
Issue number4
StatePublished - Jul 1 2006



  • Dysmorphology
  • Gynecologic pathology
  • Proteus syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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