Unusual antigen presentation offers new insight into HIV vaccine design

Andrew J. McMichael, Louis J. Picker

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalCurrent opinion in immunology
Volume46
DOIs
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Unusual antigen presentation offers new insight into HIV vaccine design'. Together they form a unique fingerprint.

  • Cite this