Unusual antigen presentation offers new insight into HIV vaccine design

Andrew J. McMichael, Louis Picker

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalCurrent Opinion in Immunology
Volume46
DOIs
StatePublished - Jun 1 2017

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AIDS Vaccines
Antigen Presentation
T-Lymphocytes
Natural Killer Cell Receptors
Simian Immunodeficiency Virus
Mycobacterium
Protein Sorting Signals
Macaca mulatta
Cytomegalovirus
Epitopes
Vaccines
Peptides

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Unusual antigen presentation offers new insight into HIV vaccine design. / McMichael, Andrew J.; Picker, Louis.

In: Current Opinion in Immunology, Vol. 46, 01.06.2017, p. 75-81.

Research output: Contribution to journalReview article

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