Unshuntable extrahepatic portal hypertension revisited: 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices

Marshall J. Orloff, Mark S. Orloff, Susan Orloff, Lisa A. Orloff, Pat O. Daily, Barbara Girard, Jon I. Isenberg, Henry O. Wheeler

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background In 1994, the authors reported their experience with radical esophagogastrectomy for bleeding esophagogastric varices due to unshuntable extra-hepatic portal hypertension. Since then, the series has expanded from 22 to 44 patients. The aim of this study was to assess the validity of the previous observations and conclusions in the largest series with the longest follow-up. Methods From 1968 to 2005, 44 patients with unshuntable extra-hepatic portal hypertension were treated by total gastrectomy and resection of the distal two thirds of the esophagus. Before referral, the patients experienced 4 to 24 episodes of variceal bleeding requiring a mean 130 U of blood transfusion, 15 hospital admissions, and 6 previous unsuccessful operations. Results Transient postoperative complications occurred in 50% of patients. The survival rate is 100%, with no recurrence of variceal bleeding during 7 to 43 years of follow-up. Liver function and biopsy results have been normal. Quality of life has been excellent or good in 91%. Eighty-six percent have resumed employment or full-time housekeeping. Conclusions In unshuntable extra-hepatic portal hypertension, radical esophagogastrectomy is the only consistently effective treatment of variceal hemorrhage. Prompt use of this lifesaving procedure is warranted.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalAmerican Journal of Surgery
Volume207
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Varicose Veins
Portal Hypertension
Hemorrhage
Liver
Housekeeping
Therapeutics
Gastrectomy
Blood Transfusion
Esophagus
Referral and Consultation
Survival Rate
Quality of Life
Biopsy
Recurrence

Keywords

  • Bleeding esophagogastric varices
  • Radical esophagogastrectomy
  • Unshuntable extrahepatic portal hypertension

ASJC Scopus subject areas

  • Surgery

Cite this

Unshuntable extrahepatic portal hypertension revisited : 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices. / Orloff, Marshall J.; Orloff, Mark S.; Orloff, Susan; Orloff, Lisa A.; Daily, Pat O.; Girard, Barbara; Isenberg, Jon I.; Wheeler, Henry O.

In: American Journal of Surgery, Vol. 207, No. 1, 01.2014, p. 46-52.

Research output: Contribution to journalArticle

Orloff, Marshall J. ; Orloff, Mark S. ; Orloff, Susan ; Orloff, Lisa A. ; Daily, Pat O. ; Girard, Barbara ; Isenberg, Jon I. ; Wheeler, Henry O. / Unshuntable extrahepatic portal hypertension revisited : 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices. In: American Journal of Surgery. 2014 ; Vol. 207, No. 1. pp. 46-52.
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