Unscheduled bleeding with continuous oral contraceptive pills: A comparison of progestin dose

Bliss Kaneshiro, Alison Edelman, Nichole E. Carlson, Mark Nichols, Jeffrey Jensen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although the use of continuous oral contraceptive pills (OCPs) eliminates scheduled uterine bleeding, unscheduled bleeding is common. The objective of this study was to determine whether progestin dose influences bleeding with use of continuous OCPs. Study Design: This was a secondary data analysis of two other studies of continuous OCPs. Women were eligible if they were switching from a cyclic hormonal contraceptive to a continuous OCP. Women took a 20-mcg ethinyl estradiol (EE)/100-mcg levonorgestrel (LNG) pill or a 20-mcg EE/90-mcg LNG pill for 112 days. The number of bleeding/spotting days was compared between groups using a t test. Sample size was adequate to detect a difference of 8 days of bleeding/spotting over the 112 day study period (β=0.80, α=0.05). Results: Sixty-six subjects were enrolled, 33 in each group. There were no differences in baseline characteristic, missed OCPs or side effects. There were no differences in the mean number of bleeding/spotting days in the first 84 days of the study (90 mcg LNG mean 20.8 (SE 3.6) days versus 100 mcg LNG 17.8 (SE 2.3) days, p=.48), nor was there a difference in the time to amenorrhea (p=.35). Conclusion: Our results do not support the use of one LNG dose over another to decrease the amount of unscheduled bleeding women experience when initiating a continuous OCP.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalContraception
Volume86
Issue number1
DOIs
StatePublished - Jul 2012

Fingerprint

Progestins
Levonorgestrel
Oral Contraceptives
Hemorrhage
Metrorrhagia
Ethinyl Estradiol
Uterine Hemorrhage
Amenorrhea
Contraceptive Agents
Sample Size

Keywords

  • Bleeding
  • Continuous oral contraceptive pills
  • Contraceptive- induced amenorrhea
  • Progestin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Unscheduled bleeding with continuous oral contraceptive pills : A comparison of progestin dose. / Kaneshiro, Bliss; Edelman, Alison; Carlson, Nichole E.; Nichols, Mark; Jensen, Jeffrey.

In: Contraception, Vol. 86, No. 1, 07.2012, p. 22-27.

Research output: Contribution to journalArticle

Kaneshiro, Bliss ; Edelman, Alison ; Carlson, Nichole E. ; Nichols, Mark ; Jensen, Jeffrey. / Unscheduled bleeding with continuous oral contraceptive pills : A comparison of progestin dose. In: Contraception. 2012 ; Vol. 86, No. 1. pp. 22-27.
@article{02045705c0984da78848b33e5446258e,
title = "Unscheduled bleeding with continuous oral contraceptive pills: A comparison of progestin dose",
abstract = "Background: Although the use of continuous oral contraceptive pills (OCPs) eliminates scheduled uterine bleeding, unscheduled bleeding is common. The objective of this study was to determine whether progestin dose influences bleeding with use of continuous OCPs. Study Design: This was a secondary data analysis of two other studies of continuous OCPs. Women were eligible if they were switching from a cyclic hormonal contraceptive to a continuous OCP. Women took a 20-mcg ethinyl estradiol (EE)/100-mcg levonorgestrel (LNG) pill or a 20-mcg EE/90-mcg LNG pill for 112 days. The number of bleeding/spotting days was compared between groups using a t test. Sample size was adequate to detect a difference of 8 days of bleeding/spotting over the 112 day study period (β=0.80, α=0.05). Results: Sixty-six subjects were enrolled, 33 in each group. There were no differences in baseline characteristic, missed OCPs or side effects. There were no differences in the mean number of bleeding/spotting days in the first 84 days of the study (90 mcg LNG mean 20.8 (SE 3.6) days versus 100 mcg LNG 17.8 (SE 2.3) days, p=.48), nor was there a difference in the time to amenorrhea (p=.35). Conclusion: Our results do not support the use of one LNG dose over another to decrease the amount of unscheduled bleeding women experience when initiating a continuous OCP.",
keywords = "Bleeding, Continuous oral contraceptive pills, Contraceptive- induced amenorrhea, Progestin",
author = "Bliss Kaneshiro and Alison Edelman and Carlson, {Nichole E.} and Mark Nichols and Jeffrey Jensen",
year = "2012",
month = "7",
doi = "10.1016/j.contraception.2011.11.003",
language = "English (US)",
volume = "86",
pages = "22--27",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Unscheduled bleeding with continuous oral contraceptive pills

T2 - A comparison of progestin dose

AU - Kaneshiro, Bliss

AU - Edelman, Alison

AU - Carlson, Nichole E.

AU - Nichols, Mark

AU - Jensen, Jeffrey

PY - 2012/7

Y1 - 2012/7

N2 - Background: Although the use of continuous oral contraceptive pills (OCPs) eliminates scheduled uterine bleeding, unscheduled bleeding is common. The objective of this study was to determine whether progestin dose influences bleeding with use of continuous OCPs. Study Design: This was a secondary data analysis of two other studies of continuous OCPs. Women were eligible if they were switching from a cyclic hormonal contraceptive to a continuous OCP. Women took a 20-mcg ethinyl estradiol (EE)/100-mcg levonorgestrel (LNG) pill or a 20-mcg EE/90-mcg LNG pill for 112 days. The number of bleeding/spotting days was compared between groups using a t test. Sample size was adequate to detect a difference of 8 days of bleeding/spotting over the 112 day study period (β=0.80, α=0.05). Results: Sixty-six subjects were enrolled, 33 in each group. There were no differences in baseline characteristic, missed OCPs or side effects. There were no differences in the mean number of bleeding/spotting days in the first 84 days of the study (90 mcg LNG mean 20.8 (SE 3.6) days versus 100 mcg LNG 17.8 (SE 2.3) days, p=.48), nor was there a difference in the time to amenorrhea (p=.35). Conclusion: Our results do not support the use of one LNG dose over another to decrease the amount of unscheduled bleeding women experience when initiating a continuous OCP.

AB - Background: Although the use of continuous oral contraceptive pills (OCPs) eliminates scheduled uterine bleeding, unscheduled bleeding is common. The objective of this study was to determine whether progestin dose influences bleeding with use of continuous OCPs. Study Design: This was a secondary data analysis of two other studies of continuous OCPs. Women were eligible if they were switching from a cyclic hormonal contraceptive to a continuous OCP. Women took a 20-mcg ethinyl estradiol (EE)/100-mcg levonorgestrel (LNG) pill or a 20-mcg EE/90-mcg LNG pill for 112 days. The number of bleeding/spotting days was compared between groups using a t test. Sample size was adequate to detect a difference of 8 days of bleeding/spotting over the 112 day study period (β=0.80, α=0.05). Results: Sixty-six subjects were enrolled, 33 in each group. There were no differences in baseline characteristic, missed OCPs or side effects. There were no differences in the mean number of bleeding/spotting days in the first 84 days of the study (90 mcg LNG mean 20.8 (SE 3.6) days versus 100 mcg LNG 17.8 (SE 2.3) days, p=.48), nor was there a difference in the time to amenorrhea (p=.35). Conclusion: Our results do not support the use of one LNG dose over another to decrease the amount of unscheduled bleeding women experience when initiating a continuous OCP.

KW - Bleeding

KW - Continuous oral contraceptive pills

KW - Contraceptive- induced amenorrhea

KW - Progestin

UR - http://www.scopus.com/inward/record.url?scp=84862019208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862019208&partnerID=8YFLogxK

U2 - 10.1016/j.contraception.2011.11.003

DO - 10.1016/j.contraception.2011.11.003

M3 - Article

C2 - 22176792

AN - SCOPUS:84862019208

VL - 86

SP - 22

EP - 27

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 1

ER -