Unscheduled apoptosis during acute inflammatory lung injury

Lin L. Mantell, Jeffrey A. Kazzaz, Jing Xu, Thomas A. Palaia, Bruno Piedboeuf, Stephen (Steve) Hall, Gregory C. Rhodes, Gang Niu, Alan F. Fein, Stuart Horowitz

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Apoptosis is a mode of cell death currently thought to occur in the absence of inflammation. In contrast, inflammation follows unscheduled events such as acute tissue injury which results in necrosis, not apoptosis. We examined the relevance of this paradigm in three distinct models of acute lung injury; hyperoxia, oleic acid, and bacterial pneumonia. In every case, it was found that apoptosis is actually a prominent component of the acute and inflammatory phase of injury. Moreover, using strains of mice that are differentially sensitive to hyperoxic lung injury we observed that the percent of apoptotic cells was well correlated with the severity of lung injury. These observations suggest that apoptosis may be one of the biological consequences during acute injury and the failure to remove these apoptotic cells may also contribute to the inflammatory response.

Original languageEnglish (US)
Pages (from-to)600-607
Number of pages8
JournalCell Death and Differentiation
Volume4
Issue number7
StatePublished - 1997

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Acute Lung Injury
Apoptosis
Lung Injury
Wounds and Injuries
Inflammation
Bacterial Pneumonia
Hyperoxia
Oleic Acid
Cell Death
Necrosis

Keywords

  • Hyperoxia
  • Necrosis
  • Oleic acid
  • Programmed cell death

ASJC Scopus subject areas

  • Cell Biology

Cite this

Mantell, L. L., Kazzaz, J. A., Xu, J., Palaia, T. A., Piedboeuf, B., Hall, S. S., ... Horowitz, S. (1997). Unscheduled apoptosis during acute inflammatory lung injury. Cell Death and Differentiation, 4(7), 600-607.

Unscheduled apoptosis during acute inflammatory lung injury. / Mantell, Lin L.; Kazzaz, Jeffrey A.; Xu, Jing; Palaia, Thomas A.; Piedboeuf, Bruno; Hall, Stephen (Steve); Rhodes, Gregory C.; Niu, Gang; Fein, Alan F.; Horowitz, Stuart.

In: Cell Death and Differentiation, Vol. 4, No. 7, 1997, p. 600-607.

Research output: Contribution to journalArticle

Mantell, LL, Kazzaz, JA, Xu, J, Palaia, TA, Piedboeuf, B, Hall, SS, Rhodes, GC, Niu, G, Fein, AF & Horowitz, S 1997, 'Unscheduled apoptosis during acute inflammatory lung injury', Cell Death and Differentiation, vol. 4, no. 7, pp. 600-607.
Mantell LL, Kazzaz JA, Xu J, Palaia TA, Piedboeuf B, Hall SS et al. Unscheduled apoptosis during acute inflammatory lung injury. Cell Death and Differentiation. 1997;4(7):600-607.
Mantell, Lin L. ; Kazzaz, Jeffrey A. ; Xu, Jing ; Palaia, Thomas A. ; Piedboeuf, Bruno ; Hall, Stephen (Steve) ; Rhodes, Gregory C. ; Niu, Gang ; Fein, Alan F. ; Horowitz, Stuart. / Unscheduled apoptosis during acute inflammatory lung injury. In: Cell Death and Differentiation. 1997 ; Vol. 4, No. 7. pp. 600-607.
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