TY - JOUR
T1 - Unraveling the miswired connectome
T2 - A developmental perspective
AU - DiMartino, Adriana
AU - Fair, Damien A.
AU - Kelly, Clare
AU - Satterthwaite, Theodore D.
AU - Castellanos, F. Xavier
AU - Thomason, Moriah E.
AU - Craddock, R. Cameron
AU - Luna, Beatriz
AU - Leventhal, Bennett L.
AU - Zuo, Xi Nian
AU - Milham, Michael P.
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014
Y1 - 2014
N2 - The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric invivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.
AB - The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric invivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.
UR - http://www.scopus.com/inward/record.url?scp=84922023688&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922023688&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2014.08.050
DO - 10.1016/j.neuron.2014.08.050
M3 - Review article
C2 - 25233316
AN - SCOPUS:84922023688
SN - 0896-6273
VL - 83
SP - 1335
EP - 1353
JO - Neuron
JF - Neuron
IS - 6
ER -