Unintentional pediatric superwarfarin exposures: Do we really need a prothrombin time?

Michael E. Mullins, Christina L. Brands, Mohamud R. Daya

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Objective. To determine whether routine follow-up coagulation studies are useful in children with accidental exposures to rodenticides containing superwarfarin compounds. Design. Retrospective review of poison center charts involving pediatric superwarfarin exposures occurring in two 2-year periods. Setting. An American Association of Poison Control Centers-certified regional poison control center with an annual call volume of 55 000 calls per year from a 2-state area with a combined population of 4 million people. Outcome Measures. Prothrombin times and/or international normalized ratios and reported clinical signs of excessive anticoagulation after exposure. Results. Of 542 children in 4 years of data collection, follow-up prothrombin times and/or international normalized ratios measurements did not detect any significant coagulation abnormalities. No child developed bleeding complications. No child required or received antidotal treatment with vitamin K. Conclusion. Normal preschool-aged children with unintentional acute exposures to superwarfarin rodenticides do not require any routine follow-up laboratory studies and do not require any medical intervention.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
JournalPediatrics
Volume105
Issue number2
DOIs
StatePublished - Feb 2000

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Keywords

  • Anticoagulant
  • Children
  • Poisoning
  • Rodenticide

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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