Unintended effects of cranial irradiation on cognitive function

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalToxicologic Pathology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Fear conditioning
  • Hippocampus
  • Irradiation
  • Mice
  • Neurogenesis
  • Oxidative stress
  • Water maze

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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