Unintended effects of cranial irradiation on cognitive function

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalToxicologic Pathology
Volume38
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Cranial Irradiation
Neurogenesis
Genetic Predisposition to Disease
Sex Characteristics
Cognition
Oxidative Stress
Irradiation
Pathology
Oxidative stress
Neoplasms
Therapeutics

Keywords

  • Fear conditioning
  • Hippocampus
  • Irradiation
  • Mice
  • Neurogenesis
  • Oxidative stress
  • Water maze

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology
  • Molecular Biology

Cite this

Unintended effects of cranial irradiation on cognitive function. / Raber, Jacob.

In: Toxicologic Pathology, Vol. 38, No. 1, 01.2010, p. 198-202.

Research output: Contribution to journalArticle

@article{1c41b34ffd98468b86ba2b4af4a0cda3,
title = "Unintended effects of cranial irradiation on cognitive function",
abstract = "This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.",
keywords = "Fear conditioning, Hippocampus, Irradiation, Mice, Neurogenesis, Oxidative stress, Water maze",
author = "Jacob Raber",
year = "2010",
month = "1",
doi = "10.1177/0192623309352003",
language = "English (US)",
volume = "38",
pages = "198--202",
journal = "Toxicologic Pathology",
issn = "0192-6233",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Unintended effects of cranial irradiation on cognitive function

AU - Raber, Jacob

PY - 2010/1

Y1 - 2010/1

N2 - This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

AB - This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

KW - Fear conditioning

KW - Hippocampus

KW - Irradiation

KW - Mice

KW - Neurogenesis

KW - Oxidative stress

KW - Water maze

UR - http://www.scopus.com/inward/record.url?scp=77952294421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952294421&partnerID=8YFLogxK

U2 - 10.1177/0192623309352003

DO - 10.1177/0192623309352003

M3 - Article

C2 - 19880825

AN - SCOPUS:77952294421

VL - 38

SP - 198

EP - 202

JO - Toxicologic Pathology

JF - Toxicologic Pathology

SN - 0192-6233

IS - 1

ER -