Unintended effects of cranial irradiation on cognitive function

Jacob Raber

doi:10.1177/0192623309352003

Unintended effects of cranial irradiation on cognitive function

Jacob Raber

Behavioral Neuroscience

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

This review summarizes some of the topics discussed at the 28th Annual Symposium of the Society of Toxicologic Pathology. The symposium was held in Washington, DC, in 2009 and dealt with unintended adverse events associated with cranial irradiation as part of cancer therapy. We will discuss the importance of considering genetic susceptibility and sex differences in susceptibility to develop these adverse events. Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers.

Original language	English (US)
Pages (from-to)	198-202
Number of pages	5
Journal	Toxicologic Pathology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1177/0192623309352003
State	Published - Jan 2010

Keywords

Fear conditioning
Hippocampus
Irradiation
Mice
Neurogenesis
Oxidative stress
Water maze

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Toxicology
Cell Biology

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10.1177/0192623309352003

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KW - Mice

KW - Neurogenesis

KW - Oxidative stress

KW - Water maze

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Unintended effects of cranial irradiation on cognitive function

Abstract

Keywords

ASJC Scopus subject areas

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