Uniformity detector retinal ganglion cells fire complex spikes and receive only light-evoked inhibition

Benjamin Sivyer, W. Rowland Taylor, David I. Vaney

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Retinal ganglion cells convey information by increasing their firing in response to an optimal visual stimulus or "trigger feature." However, one class of ganglion cell responds to changes in the visual scene by decreasing its firing. These cells, termed uniformity detectors in the rabbit retina, are encountered only rarely and the synaptic mechanisms underlying their unusual responses have not been investigated. In this study, patch-clamp recordings of uniformity detectors show that the action potentials underlying the maintained firing arise within "complex spikes." Both ON and OFF visual stimuli elicit only inhibitory synaptic input, the immediate effect of which is to suppress the maintained firing. However, this inhibition also alters the properties of the "renascent" spiking by increasing the amplitude of the spikes within each burst, suggesting that the effect may increase the efficacy of spike propagation and transmission.

Original languageEnglish (US)
Pages (from-to)5628-5633
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number12
DOIs
StatePublished - Mar 23 2010

Keywords

  • Calcium spike
  • Glycine
  • Na-channel inactivation
  • Rabbit
  • Suppressed by contrast

ASJC Scopus subject areas

  • General

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