Abstract
The clinical characteristics, follow-up and prognosis of unexplained pulmonary hypertension (UPHT) in 8 older patients, age at diagnosis 62.5 ± 11.6 years (Mean ± 1 SD, range 51 to 82), were evaluated. Seven of the patients were women. Systolic pulmonary artery pressure (PAP) at diagnosis was 87 ± 10 mm Hg (Mean ± 1 SD, range 70 to 100). A majority of the patients (7/8) had advanced disease at diagnosis (New York Heart Association classes 3 and 4) with right heart failure (RHF) as the presenting symptom in 6 of the 8 patients (75%). Following treatment with calcium channel blockers, diuretics, oxygen and anticoagulants, functional capacity and symptoms of RHF, but not PAP, improved in 4 patients (50%). These patients are alive 37 ± 11 months (Mean ± 1 SD, range 23 to 53) after diagnosis. Four patients died after a mean follow-up of 6.8 ± 7.6 months (Mean ± 1 SD, range 2 to 18). One of these patients died suddenly and another 3 died with intractable RHF. Our study shows that most newly diagnosed older patients with UPHT in our institute were women. RHF at diagnosis, a sign that indicates a poor prognosis in younger patients with UPHT, is common in older patients with UPHT and was not associated with a particularly poor prognosis. Clinical response to medical treatment, rather than PAP changes, was associated with improved outcome.
Original language | English (US) |
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Pages (from-to) | 9-15 |
Number of pages | 7 |
Journal | Journal of Cardiovascular Diagnosis and Procedures |
Volume | 14 |
Issue number | 1 |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Cardiology and Cardiovascular Medicine