Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling

Edward Allan Racela Sison, Peter Kurre, Yong Mi Kim

Research output: Contribution to journalArticle

Abstract

Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell–cell crosstalk the bone marrow microenvironment in acute leukemia was presented at the 2016 annual Therapeutic Advances in Childhood Leukemia (TACL) investigator meeting. This review summarizes the mini-symposium proceedings and focuses on chemokine signaling via the cell surface receptor CXCR4, adhesion molecule signaling via integrin α4, and crosstalk between leukemia cells and the bone marrow microenvironment that is mediated through extracellular vesicles.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalPediatric Hematology and Oncology
DOIs
StateAccepted/In press - Dec 5 2017

Fingerprint

Hematologic Neoplasms
Chemokines
Integrins
Leukemia
Bone Marrow
Bone Marrow Cells
Cell Surface Receptors
Cell Survival
Research Personnel
Extracellular Vesicles
Drug Therapy
Growth
Research

Keywords

  • Bone marrow microenvironment
  • CXCR4
  • extracellular vesicles
  • integrin
  • leukemia
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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