Understanding the biology of animal viruses and the physiopathology of animal viral diseases through genomics, proteomics and systems biology

Nagendra R. Hegde, Daniel Streblow

Research output: Contribution to journalArticle

Abstract

The recent burst in technology which followed the advent of genomic arrays has led to better understanding of the complex inter-relationship between microbes, their hosts and the environment. In addition, holistic approaches to study physiology have made it possible to evaluate the contribution of multiple elements on a single platform. Biology of viruses and their interaction with the host, the pathological consequences of virus infection to the host, and the environmental and host genetic influences on all these are areas of intense investigation. Recent transcriptome and proteome analyses have unearthed a wealth of information on how viruses replicate, survive in the host, spread and cause disease and how the host responds to infection. In this review, we summarize some of the advances in genomic, proteomic and systems biology approaches to understand virus-host interaction and pathogenesis of viral diseases. These studies have broad and important implications for the identification of anti-viral targets and for rational design of clinical interventions.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalInternational Journal of Integrative Biology
Volume2
Issue number1
StatePublished - 2008

Fingerprint

viral diseases of animals and humans
viral disease
Animal Diseases
Systems Biology
proteomics
Virus Diseases
pathophysiology
Genomics
Viruses
Proteomics
genomics
virus
Animals
Biological Sciences
animal
Gene Expression Profiling
viruses
Proteome
Physiology
Technology

Keywords

  • Animal viruses
  • Genomics
  • Proteomics
  • Systems biology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Earth and Planetary Sciences(all)
  • Environmental Science(all)
  • Neuroscience(all)

Cite this

@article{03706f5c22344885bbc19fd6210ef9fc,
title = "Understanding the biology of animal viruses and the physiopathology of animal viral diseases through genomics, proteomics and systems biology",
abstract = "The recent burst in technology which followed the advent of genomic arrays has led to better understanding of the complex inter-relationship between microbes, their hosts and the environment. In addition, holistic approaches to study physiology have made it possible to evaluate the contribution of multiple elements on a single platform. Biology of viruses and their interaction with the host, the pathological consequences of virus infection to the host, and the environmental and host genetic influences on all these are areas of intense investigation. Recent transcriptome and proteome analyses have unearthed a wealth of information on how viruses replicate, survive in the host, spread and cause disease and how the host responds to infection. In this review, we summarize some of the advances in genomic, proteomic and systems biology approaches to understand virus-host interaction and pathogenesis of viral diseases. These studies have broad and important implications for the identification of anti-viral targets and for rational design of clinical interventions.",
keywords = "Animal viruses, Genomics, Proteomics, Systems biology",
author = "Hegde, {Nagendra R.} and Daniel Streblow",
year = "2008",
language = "English (US)",
volume = "2",
pages = "32--42",
journal = "International Journal of Integrative Biology",
issn = "0974-2816",
publisher = "Omics Publishing Group",
number = "1",

}

TY - JOUR

T1 - Understanding the biology of animal viruses and the physiopathology of animal viral diseases through genomics, proteomics and systems biology

AU - Hegde, Nagendra R.

AU - Streblow, Daniel

PY - 2008

Y1 - 2008

N2 - The recent burst in technology which followed the advent of genomic arrays has led to better understanding of the complex inter-relationship between microbes, their hosts and the environment. In addition, holistic approaches to study physiology have made it possible to evaluate the contribution of multiple elements on a single platform. Biology of viruses and their interaction with the host, the pathological consequences of virus infection to the host, and the environmental and host genetic influences on all these are areas of intense investigation. Recent transcriptome and proteome analyses have unearthed a wealth of information on how viruses replicate, survive in the host, spread and cause disease and how the host responds to infection. In this review, we summarize some of the advances in genomic, proteomic and systems biology approaches to understand virus-host interaction and pathogenesis of viral diseases. These studies have broad and important implications for the identification of anti-viral targets and for rational design of clinical interventions.

AB - The recent burst in technology which followed the advent of genomic arrays has led to better understanding of the complex inter-relationship between microbes, their hosts and the environment. In addition, holistic approaches to study physiology have made it possible to evaluate the contribution of multiple elements on a single platform. Biology of viruses and their interaction with the host, the pathological consequences of virus infection to the host, and the environmental and host genetic influences on all these are areas of intense investigation. Recent transcriptome and proteome analyses have unearthed a wealth of information on how viruses replicate, survive in the host, spread and cause disease and how the host responds to infection. In this review, we summarize some of the advances in genomic, proteomic and systems biology approaches to understand virus-host interaction and pathogenesis of viral diseases. These studies have broad and important implications for the identification of anti-viral targets and for rational design of clinical interventions.

KW - Animal viruses

KW - Genomics

KW - Proteomics

KW - Systems biology

UR - http://www.scopus.com/inward/record.url?scp=84946085528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946085528&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 32

EP - 42

JO - International Journal of Integrative Biology

JF - International Journal of Integrative Biology

SN - 0974-2816

IS - 1

ER -