Understanding diverse TRPV1 signaling – an update [version 1; peer review: 4 approved]

Research output: Contribution to journalReview article

Abstract

The transient receptor potential vanilloid 1 (TRPV1) is densely expressed in spinal sensory neurons as well as in cranial sensory neurons, including their central terminal endings. Recent work in the less familiar cranial sensory neurons, despite their many similarities with spinal sensory neurons, suggest that TRPV1 acts as a calcium channel to release a discrete population of synaptic vesicles. The modular and independent regulation of release offers new questions about nanodomain organization of release and selective actions of G protein–coupled receptors.

Original languageEnglish (US)
Article number1978
JournalF1000Research
Volume8
DOIs
StatePublished - Jan 1 2019

    Fingerprint

Keywords

  • Cranial nerve
  • NTS
  • Solitary tract nucleus
  • Synaptic transmission
  • TRPV1
  • Vagus
  • Visceral afferent

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this