TY - JOUR
T1 - Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels
AU - Baconguis, Isabelle
AU - Hattori, Motoyuki
AU - Gouaux, Eric
PY - 2013/4
Y1 - 2013/4
N2 - ATP-gated P2X receptors and acid-sensing ion channels are cation-selective, trimeric ligand-gated ion channels unrelated in amino acid sequence. Nevertheless, initial crystal structures of the P2X4 receptor and acid-sensing ion channel 1a in resting/closed and in non conductive/desensitized conformations, respectively, revealed common elements of architecture. Recent structures of both channels have revealed the ion channels in open conformations. Here we focus on common elements of architecture, conformational change and ion permeation, emphasizing general principles of structure and mechanism in P2X receptors and in acid-sensing ion channels and showing how these two sequence-disparate families of ligand-gated ion channel harbor unexpected similarities when viewed through a structural lens.
AB - ATP-gated P2X receptors and acid-sensing ion channels are cation-selective, trimeric ligand-gated ion channels unrelated in amino acid sequence. Nevertheless, initial crystal structures of the P2X4 receptor and acid-sensing ion channel 1a in resting/closed and in non conductive/desensitized conformations, respectively, revealed common elements of architecture. Recent structures of both channels have revealed the ion channels in open conformations. Here we focus on common elements of architecture, conformational change and ion permeation, emphasizing general principles of structure and mechanism in P2X receptors and in acid-sensing ion channels and showing how these two sequence-disparate families of ligand-gated ion channel harbor unexpected similarities when viewed through a structural lens.
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U2 - 10.1016/j.sbi.2013.04.005
DO - 10.1016/j.sbi.2013.04.005
M3 - Review article
C2 - 23628284
AN - SCOPUS:84878601303
SN - 0959-440X
VL - 23
SP - 277
EP - 284
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 2
ER -