Ultrastructure of cellular congenital mesoblastic nephroma

Dennis P. O'Malley, Gary W. Mierau, J. Bruce Beckwith, Douglas Weeks

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A detailed ultrastructural description of the cellular variant of congenital mesoblastic nephroma (CMN) is presented and compared to the classical form. Studied were 9 cases of the cellular variant, 6 mixed (cellular/classical) tumors, and 1 classical CMN. The occurrence of a broad selection of ultrastructural features was assessed using a semiquantitative scoring system. The results indicate that cellular CMNs are composed mainly of primitive mesenchymal cells, but also usually contain varying numbers of differentiating fibroblasts and myofibroblasts. This entity thus bears a closer resemblance at the ultrastructural level of organization to infantile fibrosarcoma than to conventional fibrosarcoma. Electron microscopy can be useful in distinguishing this relatively benign entity from the several malignancies with which it is sometimes confused.

Original languageEnglish (US)
Pages (from-to)417-427
Number of pages11
JournalUltrastructural Pathology
Volume20
Issue number5
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • Clear cell sarcoma of kidney
  • Congenital mesoblastic nephroma
  • Electron microscopy
  • Immunohistochemistry
  • Rhabdoid tumor of kidney
  • Wilms' tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

Cite this

O'Malley, D. P., Mierau, G. W., Beckwith, J. B., & Weeks, D. (1996). Ultrastructure of cellular congenital mesoblastic nephroma. Ultrastructural Pathology, 20(5), 417-427.