Ultrastructural Location of Extracellular Matrix Components in the Optic Nerve Head

John Morrison, Nancy L. L'hernault, Harry A. Quigley, Janice A. Jerdan

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The distributions of laminin and collagen types I through V were determined in optic nerve heads of cynomolgus monkeys using colloidal gold immunoelectron microscopy. Collagen types I and III localized to striated collagen fibrils in arterial walls throughout the optic nerve head and to fibrils comprising the core of the lamina cribrosa beams and optic nerve septa. Collagen type IV and laminin localized to basement membranes of all blood vessels and to basement membranes of astrocytes that lie between the laminar beams and line the optic nerve septa and pia mater. Collagen type V was detected both in striated collagen fibrils and in vascular and astrocyte basement membranes. These results provide a detailed understanding of the optic nerve head extracellular matrix distribution and illustrate a sensitive method for future study of its role in glaucomatous optic nerve damage.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalArchives of Ophthalmology
Volume107
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Optic Disk
Optic Nerve
Basement Membrane
Extracellular Matrix
Laminin
Collagen Type I
Astrocytes
Blood Vessels
Collagen
Pia Mater
Collagen Type V
Gold Colloid
Collagen Type III
Macaca fascicularis
Collagen Type IV
Immunoelectron Microscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ultrastructural Location of Extracellular Matrix Components in the Optic Nerve Head. / Morrison, John; L'hernault, Nancy L.; Quigley, Harry A.; Jerdan, Janice A.

In: Archives of Ophthalmology, Vol. 107, No. 1, 1989, p. 123-129.

Research output: Contribution to journalArticle

Morrison, John ; L'hernault, Nancy L. ; Quigley, Harry A. ; Jerdan, Janice A. / Ultrastructural Location of Extracellular Matrix Components in the Optic Nerve Head. In: Archives of Ophthalmology. 1989 ; Vol. 107, No. 1. pp. 123-129.
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