Plasma lipoprotein alterations in 3 groups of patients with diabetic eruptive xanthomas, tuberous xanthomas and palpebral xanthelasmas are related to the lipids accumulating in each form of xanthoma. The results of routine and special histochemical electron microscopic examination of the xanthomas are correlated with lipid analyses in the 3 varieties of xanthoma. The findings suggest that the major circulatory lipoprotein(s) specifically contributes to the xanthoma lipids. The lipids and lipoproteins apparently permeate the vascular wall of the dermal capillaries and are then phagocytized by the histiocytic foam cells that accumulate around the numerous small vessels in the upper dermis. The 3 forms of xanthoma varied somewhat from one another in lipid composition, depending on the chemical composition of the major lipoprotein found in the circulation. These differences in the lipids and lipoproteins accumulating in the xanthomas were in turn responsible for subtle differences in the ultrastructure of each group of xanthomas.
|Original language||English (US)|
|Number of pages||29|
|Journal||Israel Journal of Medical Sciences|
|State||Published - Dec 1 1973|
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