Ultrasound-modulated optical tomography for thick tissue imaging

Lihong Wang, Xuemei Zhao, Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Continuous-wave ultrasonic modulation of scattered laser light has been used to image objects in tissue-simulating turbid media for the first time. We hypothesize that the ultrasound wave focused into the turbid media modulates the laser light passing through the ultrasonic focal spot. The modulated laser light collected by a photomultiplier tube reflects the local mechanical and optical properties in the focal zone. Buried objects in 5-cm thick tissue phantoms are located with millimeter resolution by scanning and detecting alterations of the ultrasound-modulated optical signal. Ultrasound-modulated optical tomography separates the conflict between signal and resolution in purely optical imaging of tissue and does not rely on ballistic or quasi-ballistic photons but on the abundant diffuse photons. The imaging resolution is determined by the focused ultrasonic wave. This technique has the potential to provide a noninvasive, nonionizing, inexpensive diagnostic tool for diseases such as breast cancer.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsBritton Chance, David T. Delpy, Gerhard J. Mueller
Pages237-248
Number of pages12
StatePublished - Dec 1 1995
EventPhoton Propagation in Tissues - Barcelona, Spain
Duration: Sep 13 1995Sep 14 1995

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2626
ISSN (Print)0277-786X

Other

OtherPhoton Propagation in Tissues
CityBarcelona, Spain
Period9/13/959/14/95

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Wang, L., Zhao, X., & Jacques, S. L. (1995). Ultrasound-modulated optical tomography for thick tissue imaging. In B. Chance, D. T. Delpy, & G. J. Mueller (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 237-248). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2626).