Ultrasound mediated localized drug delivery

Stuart Ibsen, Michael Benchimol, Dmitri Simberg, Sadik Esener

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue. Slow release carriers have been developed which reduce the exposure to healthy tissue but this slow release also limits the maximum levels of drug in the tumor and nonspecific accumulation in healthy tissue remains a major hurdle. The next advance is to design these carriers to produce a rapid burst release of drug, but only in response to a localized trigger. The trigger of choice is low intensity focused ultrasound. A new particle is described here which incorporates an ultrasound sensitive microbubble of perfluorocarbon gas within a protective liposome carrier along with the payload. It is shown that this design can accomplish the desired burst release when exposed to ultrasound focused to small spatial locations within tissue phantoms. The ability to trigger release could provide a second level of spatial and temporal control beyond biochemical targeting or passive accumulation, making these promising particles for further development.

Original languageEnglish (US)
Title of host publicationNano-Biotechnology for Biomedical and Diagnostic Research
Pages145-153
Number of pages9
Volume733
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume733
ISSN (Print)00652598

Fingerprint

Drug delivery
Ultrasonics
Tissue
Pharmaceutical Preparations
Fluorocarbons
Microbubbles
Chemotherapy
Poisons
Drug-Related Side Effects and Adverse Reactions
Liposomes
Tumors
Neoplasms
Gases
Drug Therapy
Therapeutics

Keywords

  • Burst release
  • Controlled release
  • Focused ultrasound
  • Microbubbles
  • Triggered drug delivery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ibsen, S., Benchimol, M., Simberg, D., & Esener, S. (2012). Ultrasound mediated localized drug delivery. In Nano-Biotechnology for Biomedical and Diagnostic Research (Vol. 733, pp. 145-153). (Advances in Experimental Medicine and Biology; Vol. 733). https://doi.org/10.1007/978-94-007-2555-3_14

Ultrasound mediated localized drug delivery. / Ibsen, Stuart; Benchimol, Michael; Simberg, Dmitri; Esener, Sadik.

Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733 2012. p. 145-153 (Advances in Experimental Medicine and Biology; Vol. 733).

Research output: Chapter in Book/Report/Conference proceedingChapter

Ibsen, S, Benchimol, M, Simberg, D & Esener, S 2012, Ultrasound mediated localized drug delivery. in Nano-Biotechnology for Biomedical and Diagnostic Research. vol. 733, Advances in Experimental Medicine and Biology, vol. 733, pp. 145-153. https://doi.org/10.1007/978-94-007-2555-3_14
Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. In Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733. 2012. p. 145-153. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-007-2555-3_14
Ibsen, Stuart ; Benchimol, Michael ; Simberg, Dmitri ; Esener, Sadik. / Ultrasound mediated localized drug delivery. Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733 2012. pp. 145-153 (Advances in Experimental Medicine and Biology).
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