Ultrasound mediated localized drug delivery

Stuart Ibsen, Michael Benchimol, Dmitri Simberg, Sadik Esener

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue. Slow release carriers have been developed which reduce the exposure to healthy tissue but this slow release also limits the maximum levels of drug in the tumor and nonspecific accumulation in healthy tissue remains a major hurdle. The next advance is to design these carriers to produce a rapid burst release of drug, but only in response to a localized trigger. The trigger of choice is low intensity focused ultrasound. A new particle is described here which incorporates an ultrasound sensitive microbubble of perfluorocarbon gas within a protective liposome carrier along with the payload. It is shown that this design can accomplish the desired burst release when exposed to ultrasound focused to small spatial locations within tissue phantoms. The ability to trigger release could provide a second level of spatial and temporal control beyond biochemical targeting or passive accumulation, making these promising particles for further development.

Original languageEnglish (US)
Title of host publicationNano-Biotechnology for Biomedical and Diagnostic Research
PublisherSpringer New York LLC
Pages145-153
Number of pages9
Volume733
ISBN (Print)9789400725546
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume733
ISSN (Print)00652598

Fingerprint

Drug delivery
Ultrasonics
Tissue
Pharmaceutical Preparations
Fluorocarbons
Microbubbles
Chemotherapy
Poisons
Drug-Related Side Effects and Adverse Reactions
Liposomes
Tumors
Neoplasms
Gases
Drug Therapy
Therapeutics

Keywords

  • Burst release
  • Controlled release
  • Focused ultrasound
  • Microbubbles
  • Triggered drug delivery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ibsen, S., Benchimol, M., Simberg, D., & Esener, S. (2011). Ultrasound mediated localized drug delivery. In Nano-Biotechnology for Biomedical and Diagnostic Research (Vol. 733, pp. 145-153). (Advances in Experimental Medicine and Biology; Vol. 733). Springer New York LLC. https://doi.org/10.1007/978-94-7-2555-3_14

Ultrasound mediated localized drug delivery. / Ibsen, Stuart; Benchimol, Michael; Simberg, Dmitri; Esener, Sadik.

Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733 Springer New York LLC, 2011. p. 145-153 (Advances in Experimental Medicine and Biology; Vol. 733).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ibsen, S, Benchimol, M, Simberg, D & Esener, S 2011, Ultrasound mediated localized drug delivery. in Nano-Biotechnology for Biomedical and Diagnostic Research. vol. 733, Advances in Experimental Medicine and Biology, vol. 733, Springer New York LLC, pp. 145-153. https://doi.org/10.1007/978-94-7-2555-3_14
Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. In Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733. Springer New York LLC. 2011. p. 145-153. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-7-2555-3_14
Ibsen, Stuart ; Benchimol, Michael ; Simberg, Dmitri ; Esener, Sadik. / Ultrasound mediated localized drug delivery. Nano-Biotechnology for Biomedical and Diagnostic Research. Vol. 733 Springer New York LLC, 2011. pp. 145-153 (Advances in Experimental Medicine and Biology).
@inproceedings{edfc0f5ed8434c31aabe4b7afb737dc1,
title = "Ultrasound mediated localized drug delivery",
abstract = "Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue. Slow release carriers have been developed which reduce the exposure to healthy tissue but this slow release also limits the maximum levels of drug in the tumor and nonspecific accumulation in healthy tissue remains a major hurdle. The next advance is to design these carriers to produce a rapid burst release of drug, but only in response to a localized trigger. The trigger of choice is low intensity focused ultrasound. A new particle is described here which incorporates an ultrasound sensitive microbubble of perfluorocarbon gas within a protective liposome carrier along with the payload. It is shown that this design can accomplish the desired burst release when exposed to ultrasound focused to small spatial locations within tissue phantoms. The ability to trigger release could provide a second level of spatial and temporal control beyond biochemical targeting or passive accumulation, making these promising particles for further development.",
keywords = "Burst release, Controlled release, Focused ultrasound, Microbubbles, Triggered drug delivery",
author = "Stuart Ibsen and Michael Benchimol and Dmitri Simberg and Sadik Esener",
year = "2011",
doi = "10.1007/978-94-7-2555-3_14",
language = "English (US)",
isbn = "9789400725546",
volume = "733",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "145--153",
booktitle = "Nano-Biotechnology for Biomedical and Diagnostic Research",

}

TY - GEN

T1 - Ultrasound mediated localized drug delivery

AU - Ibsen, Stuart

AU - Benchimol, Michael

AU - Simberg, Dmitri

AU - Esener, Sadik

PY - 2011

Y1 - 2011

N2 - Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue. Slow release carriers have been developed which reduce the exposure to healthy tissue but this slow release also limits the maximum levels of drug in the tumor and nonspecific accumulation in healthy tissue remains a major hurdle. The next advance is to design these carriers to produce a rapid burst release of drug, but only in response to a localized trigger. The trigger of choice is low intensity focused ultrasound. A new particle is described here which incorporates an ultrasound sensitive microbubble of perfluorocarbon gas within a protective liposome carrier along with the payload. It is shown that this design can accomplish the desired burst release when exposed to ultrasound focused to small spatial locations within tissue phantoms. The ability to trigger release could provide a second level of spatial and temporal control beyond biochemical targeting or passive accumulation, making these promising particles for further development.

AB - Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue. Slow release carriers have been developed which reduce the exposure to healthy tissue but this slow release also limits the maximum levels of drug in the tumor and nonspecific accumulation in healthy tissue remains a major hurdle. The next advance is to design these carriers to produce a rapid burst release of drug, but only in response to a localized trigger. The trigger of choice is low intensity focused ultrasound. A new particle is described here which incorporates an ultrasound sensitive microbubble of perfluorocarbon gas within a protective liposome carrier along with the payload. It is shown that this design can accomplish the desired burst release when exposed to ultrasound focused to small spatial locations within tissue phantoms. The ability to trigger release could provide a second level of spatial and temporal control beyond biochemical targeting or passive accumulation, making these promising particles for further development.

KW - Burst release

KW - Controlled release

KW - Focused ultrasound

KW - Microbubbles

KW - Triggered drug delivery

UR - http://www.scopus.com/inward/record.url?scp=84934441871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934441871&partnerID=8YFLogxK

U2 - 10.1007/978-94-7-2555-3_14

DO - 10.1007/978-94-7-2555-3_14

M3 - Conference contribution

SN - 9789400725546

VL - 733

T3 - Advances in Experimental Medicine and Biology

SP - 145

EP - 153

BT - Nano-Biotechnology for Biomedical and Diagnostic Research

PB - Springer New York LLC

ER -