Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Paul A. Dayton, Jonathan R. Lindner, James E. Chomas, Karen E. Morgan, Scott Simon, Aaron Lum, Donovan May, Matthew P. Coggins, Kathy W. Ferrara

Research output: Contribution to journalConference articlepeer-review

6 Scopus citations

Abstract

A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

Original languageEnglish (US)
Pages (from-to)1705-1708
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
Volume2
StatePublished - Dec 1 1999
Externally publishedYes
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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