Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Paul A. Dayton; Jonathan R. Lindner; James E. Chomas; Karen E. Morgan; Scott Simon; Aaron Lum; Donovan May; Matthew P. Coggins; Kathy W. Ferrara

Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Paul A. Dayton, Jonathan R. Lindner, James E. Chomas, Karen E. Morgan, Scott Simon, Aaron Lum, Donovan May, Matthew P. Coggins, Kathy W. Ferrara

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

Original language	English (US)
Pages (from-to)	1705-1708
Number of pages	4
Journal	Proceedings of the IEEE Ultrasonics Symposium
Volume	2
State	Published - 1999
Externally published	Yes
Event	1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA Duration: Oct 17 1999 → Oct 20 1999

ASJC Scopus subject areas

Acoustics and Ultrasonics

Cite this

@article{662e1774e6a04d2a884d6c2184e5705f,

title = "Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity",

abstract = "A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.",

author = "Dayton, {Paul A.} and Lindner, {Jonathan R.} and Chomas, {James E.} and Morgan, {Karen E.} and Scott Simon and Aaron Lum and Donovan May and Coggins, {Matthew P.} and Ferrara, {Kathy W.}",

year = "1999",

language = "English (US)",

volume = "2",

pages = "1705--1708",

journal = "Proceedings of the IEEE Ultrasonics Symposium",

issn = "1051-0117",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "1999 IEEE Ultrasonics Symposium ; Conference date: 17-10-1999 Through 20-10-1999",

}

TY - JOUR

T1 - Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

AU - Dayton, Paul A.

AU - Lindner, Jonathan R.

AU - Chomas, James E.

AU - Morgan, Karen E.

AU - Simon, Scott

AU - Lum, Aaron

AU - May, Donovan

AU - Coggins, Matthew P.

AU - Ferrara, Kathy W.

PY - 1999

Y1 - 1999

N2 - A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

AB - A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

UR - http://www.scopus.com/inward/record.url?scp=0033295356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033295356&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0033295356

SN - 1051-0117

VL - 2

SP - 1705

EP - 1708

JO - Proceedings of the IEEE Ultrasonics Symposium

JF - Proceedings of the IEEE Ultrasonics Symposium

T2 - 1999 IEEE Ultrasonics Symposium

Y2 - 17 October 1999 through 20 October 1999

ER -

Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this