Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

Paul A. Dayton, Jonathan Lindner, James E. Chomas, Karen E. Morgan, Scott Simon, Aaron Lum, Donovan May, Matthew P. Coggins, Kathy W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
PublisherIEEE
Pages1705-1708
Number of pages4
Volume2
StatePublished - 1999
Externally publishedYes
Event1999 IEEE Ultrasonics Symposium - Caesars Tahoe, NV, USA
Duration: Oct 17 1999Oct 20 1999

Other

Other1999 IEEE Ultrasonics Symposium
CityCaesars Tahoe, NV, USA
Period10/17/9910/20/99

Fingerprint

Ultrasonics
Acoustics
Imaging systems

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Dayton, P. A., Lindner, J., Chomas, J. E., Morgan, K. E., Simon, S., Lum, A., ... Ferrara, K. W. (1999). Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1705-1708). IEEE.

Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity. / Dayton, Paul A.; Lindner, Jonathan; Chomas, James E.; Morgan, Karen E.; Simon, Scott; Lum, Aaron; May, Donovan; Coggins, Matthew P.; Ferrara, Kathy W.

Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 IEEE, 1999. p. 1705-1708.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dayton, PA, Lindner, J, Chomas, JE, Morgan, KE, Simon, S, Lum, A, May, D, Coggins, MP & Ferrara, KW 1999, Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity. in Proceedings of the IEEE Ultrasonics Symposium. vol. 2, IEEE, pp. 1705-1708, 1999 IEEE Ultrasonics Symposium, Caesars Tahoe, NV, USA, 10/17/99.
Dayton PA, Lindner J, Chomas JE, Morgan KE, Simon S, Lum A et al. Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity. In Proceedings of the IEEE Ultrasonics Symposium. Vol. 2. IEEE. 1999. p. 1705-1708
Dayton, Paul A. ; Lindner, Jonathan ; Chomas, James E. ; Morgan, Karen E. ; Simon, Scott ; Lum, Aaron ; May, Donovan ; Coggins, Matthew P. ; Ferrara, Kathy W. / Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity. Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 IEEE, 1999. pp. 1705-1708
@inproceedings{662e1774e6a04d2a884d6c2184e5705f,
title = "Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity",
abstract = "A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.",
author = "Dayton, {Paul A.} and Jonathan Lindner and Chomas, {James E.} and Morgan, {Karen E.} and Scott Simon and Aaron Lum and Donovan May and Coggins, {Matthew P.} and Ferrara, {Kathy W.}",
year = "1999",
language = "English (US)",
volume = "2",
pages = "1705--1708",
booktitle = "Proceedings of the IEEE Ultrasonics Symposium",
publisher = "IEEE",

}

TY - GEN

T1 - Ultrasound contrast agents phagocytosed by neutrophils demonstrate acoustic activity

AU - Dayton, Paul A.

AU - Lindner, Jonathan

AU - Chomas, James E.

AU - Morgan, Karen E.

AU - Simon, Scott

AU - Lum, Aaron

AU - May, Donovan

AU - Coggins, Matthew P.

AU - Ferrara, Kathy W.

PY - 1999

Y1 - 1999

N2 - A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

AB - A study was carried out to assess the physical responses of both phagocytosed and free microbubbles by direct microscopic observation during delivery of repetitive single pulses of ultrasound at various acoustic pressures. The aim was to determine whether microbubbles can be used for contrast-enhanced ultrasound (CEU) assessment of organ perfusion. Microbubbles were optically recorded during insonation with a high-speed imaging system and diameter-time curves were analyzed to determine the effect of phagocytosis. The results indicate that CEU can be used to identify and assess regions of inflammation by detecting acoustic signals from microbubbles that are phagocytosed by activated neutrophils.

UR - http://www.scopus.com/inward/record.url?scp=0033295356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033295356&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033295356

VL - 2

SP - 1705

EP - 1708

BT - Proceedings of the IEEE Ultrasonics Symposium

PB - IEEE

ER -