Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering

Sean S. Kohles, Shelley S. Mason, Anya P. Adams, Robert J. Berg, Jessica Blank, Fay Gibson, Johnathan Righetti, Iesha S. Washington, Asit K. Saha

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Non-destructive techniques characterising the mechanical properties of cells, tissues, and biomaterials provide baseline metrics for tissue engineering design. Ultrasonic wave propagation and attenuation has previously demonstrated the dynamics of extracellular matrix synthesis in chondrocyte-seeded hydrogel constructs. In this paper, we describe an ultrasonic method to analyse two of the construct elements used to engineer articular cartilage in real-time, native cartilage explants and an agarose biomaterial. Results indicated a similarity in wave propagation velocity ranges for both longitudinal (1500-1745 m/s) and transverse (350-950 m/s) waveforms. Future work will apply an acoustoelastic analysis to distinguish between the fluid and solid properties including the cell and matrix biokinetics as a validation of previous mathematical models.

Original languageEnglish (US)
Pages (from-to)296-307
Number of pages12
JournalInternational Journal of Biomedical Engineering and Technology
Volume10
Issue number3
DOIs
StatePublished - Dec 1 2012

Keywords

  • Acoustoelasticity
  • Bioengineering
  • Biomedical engineering
  • Cartilage biokinetics
  • Cartilage engineering
  • Hydrogel biomaterials
  • Transmission wave elasticity
  • Ultrasonic elasticity

ASJC Scopus subject areas

  • Biomedical Engineering

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    Kohles, S. S., Mason, S. S., Adams, A. P., Berg, R. J., Blank, J., Gibson, F., Righetti, J., Washington, I. S., & Saha, A. K. (2012). Ultrasonic wave propagation assessment of native cartilage explants and hydrogel scaffolds for tissue engineering. International Journal of Biomedical Engineering and Technology, 10(3), 296-307. https://doi.org/10.1504/IJBET.2012.050263