TY - JOUR
T1 - Ultra-wide-field retinal imaging in the management of non-infectious retinal vasculitis
AU - Leder, Henry A.
AU - Campbell, John P.
AU - Sepah, Yasir J.
AU - Gan, Theresa
AU - Dunn, James P.
AU - Hatef, Elham
AU - Cho, Brian
AU - Ibrahim, Mohamed
AU - Bittencourt, Millena
AU - Channa, Roomasa
AU - Do, Diana V.
AU - Nguyen, Quan Dong
N1 - Funding Information:
The study is supported in part by the Uveitis Research Fund at the Wilmer Eye Institute. The Johns Hopkins University has received research aid in the form of instrument support from Optos, Inc. No direct financial support was received for this research. The research was presented in part as a paper presentation at the 2011 Meeting of the Association for Research in Vision and Ophthalmology (Fort Lauderdale, FL, USA) and at the 2011 Meeting of the American Academy of Ophthalmology (Orlando, FL, USA).
Funding Information:
The research was made possible in part through the instrument support program from Optos, Inc. to the Johns Hopkins University. There was no direct financial support for this research from Optos.
PY - 2013
Y1 - 2013
N2 - Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68%) compared with 32/71 (45%) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6%), and an additional 3 of 71 (4%) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14%), and 36/71 (51%) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.
AB - Background: The purpose of this study is to describe and quantify the benefit of ultra-wide-field imaging and fluorescein angiography (FA) in the management of non-infectious retinal vasculitis. In this prospective observational cohort series, patients with non-infectious retinal vasculitis were evaluated and enrolled by four investigators from the Divisions of Retina and Ocular Immunology at the Wilmer Eye Institute. In each patient, disease activity and the need for management changes were assessed, based on clinical examination with or without standard (60°) imaging and then with the addition of ultra-wide-field pseudo-color scanning laser ophthalmoscope (SLO) images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA™, Optos PLC, Dunfermline, Scotland, UK). A standardized questionnaire was completed by each investigator at the time of the clinical evaluation. The primary outcome was the percentage of patients whose management was changed by clinical examination and standard FA, compared with clinical examination plus ultra-wide-field imaging. The secondary outcome was the percentage of patients whose disease was determined to be active based on each modality. Results: Seventy-one visits from 23 patients were reviewed and analyzed. Based on examination plus ultra-wide-field imaging and ultra-wide-field angiography, disease activity was detected in 48/71 (68%) compared with 32/71 (45%) based on examination and standard FA (P = 0.0095). Based on the clinical examination alone, the decision to alter management was made in 4 of 71 visits (6%), and an additional 3 of 71 (4%) based on simulated standard FA. The addition of ultra-wide-field SLO pseudo-color images altered management in an additional 10/71 visits (14%), and 36/71 (51%) with the addition of ultra-wide-field FA. Conclusions: Ultra-wide-field fluorescein imaging and angiography can provide additional information that may be important and relevant in the management of retinal vasculitis.
KW - Fluorescein angiography
KW - Non-infectious retinal vasculitis
KW - Ultra-wide-field imaging
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U2 - 10.1186/1869-5760-3-30
DO - 10.1186/1869-5760-3-30
M3 - Review article
AN - SCOPUS:84891395593
SN - 1869-5760
VL - 3
SP - 1
EP - 6
JO - Journal of Ophthalmic Inflammation and Infection
JF - Journal of Ophthalmic Inflammation and Infection
IS - 1
M1 - 30
ER -