Ultra-wide-field fundus autofluorescence findings in patients with acute zonal occult outer retinopathy

Amde Selassie Shifera, Mark E. Pennesi, Paul Yang, Phoebe Lin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: To determine whether ultra-wide-field fundus autofluorescence (UWFFAF) findings in acute zonal occult outer retinopathy correlated well with perimetry, optical coherence tomography, and electroretinography findings. Methods: Retrospective observational study on 16 eyes of 10 subjects with AZOOR seen at a single referral center from October 2012 to March 2015 who had UWFFAF performed. Chi-square analysis was performed to compare categorical variables, and Mann-Whitney U test used for comparisons of nonparametric continuous variables. Results: All eyes examined within 3 months of symptom onset (five of the five eyes) had diffusely hyperautofluorescent areas on UWFFAF. The remaining eyes contained hypoautofluorescent lesions with hyperautofluorescent borders. In 11/16 (68.8%) eyes, UWFFAF showed the full extent of lesions that would not have been possible with standard fundus autofluorescence centered on the fovea. There were 3 patterns of spread: centrifugal spread (7/16, 43.8%), centripetal spread (5/16, 31.3%), and centrifugal + centripetal spread (4/16, 25.0%). The UWFFAF lesions corresponded well with perimetric, optical coherence tomography, and electroretinography abnormalities. Conclusion: The UWFFAF along with optical coherence tomography can be useful in the evaluation and monitoring of acute zonal occult outer retinopathy patients.

Original languageEnglish (US)
Pages (from-to)1104-1119
Number of pages16
JournalRetina
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • acute zonal occult outer retinopathy
  • electroretinography
  • fundus autofluorescence
  • optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology

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