@inproceedings{ff838ed938df4fceb4f0031fa5f49362,
title = "Ultra-high throughput isolation of circulating tumor cells with microfluidic vortex technology",
abstract = "Here we describe improvements for the rapid, size-based capture of circulating tumor cells (CTCs) from blood. We have previously presented the Vortex Chip [1], an inertial microfluidic device which isolates CTCs at high throughput (400 μL/min of whole blood), purity (>80%), and viability (∼80%), but was limited by ∼20% efficiency. Here, we demonstrate improved CTC capture efficiency (up to 40%) and speed of processing (up to 8 mL/min) with the High Throughput Vortex Chip (Vortex HT). We show in cancer cell lines and clinical samples that the Vortex HT purifies larger numbers of CTCs.",
keywords = "Cancer cell trapping, Cancer prognosis, Inertial microfluidics, Medical devices, Rare cell enrichment, Size-based purification, Vortex",
author = "J. Che and M. Dhar and V. Yu and Go, {D. E.} and E. Pao and M. Matsumoto and Garon, {E. B.} and J. Goldman and Kulkarni, {R. P.} and E. Sollier and {Di Carlo}, D.",
note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",
year = "2014",
language = "English (US)",
series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
publisher = "Chemical and Biological Microsystems Society",
pages = "618--620",
booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
}