Ubiquitin trafficking to the lysosome: Keeping the house tidy and getting rid of unwanted guests

Georgiana Purdy, David G. Russell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bacterial killing by autophagic delivery to the lysosomal compartment has been shown for Mycobacteria, Streptococcus, Shigella, Legionella and Salmonella, indicating an important role for this conserved trafficking pathway for the control of intracellular bacterial pathogens.1-5 In a recent study we found that solubilized lysosomes isolated from bone marrow-derived macrophages had potent antibacterial properties against M. tuberculosis and M. smegmatis that were associated with ubiquitin and ubiquitin-derived peptides. We propose that ubiquitinated proteins are delivered to the lysosomal compartment, where degradation by lysosomal proteinases generates ubiquitin-derived peptides with antimycobacterial properties. This surprising finding provokes a number of questions regarding the nature and trafficking of ubiquitin and ubiquitin-modified proteins in mammalian cells. We discuss the possible role(s) that the multivesicular body (MVB), the late endosome and the autophagosome may play in trafficking of ubiquitinated proteins to the lysosome.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalAutophagy
Volume3
Issue number4
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Ubiquitin
Lysosomes
Ubiquitinated Proteins
Smegma
Multivesicular Bodies
Legionella
Peptides
Shigella
Endosomes
Mycobacterium
Streptococcus
Salmonella
Tuberculosis
Peptide Hydrolases
Macrophages
Proteins

Keywords

  • Antimicrobial
  • Lysosome
  • Multivesicular body
  • Mycobacteria
  • Ubiquitin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Ubiquitin trafficking to the lysosome : Keeping the house tidy and getting rid of unwanted guests. / Purdy, Georgiana; Russell, David G.

In: Autophagy, Vol. 3, No. 4, 07.2007, p. 399-401.

Research output: Contribution to journalArticle

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