Tyrosine Kinase Inhibitors in Leukemia and Cardiovascular Events: From Mechanism to Patient Care

Ali Manouchehri, Elishama Kanu, Michael J. Mauro, Aaron W. Aday, Jonathan R. Lindner, Javid Moslehi

    Research output: Contribution to journalArticle

    Abstract

    Targeted oncology therapies have revolutionized cancer treatment over the last decade and have resulted in improved prognosis for many patients. This advance has emanated from elucidation of pathways responsible for tumorigenesis followed by targeting of these pathways by specific molecules. Cardiovascular care has become an increasingly critical aspect of patient care in part because patients live longer, but also due to potential associated toxicities from these therapies. Because of the targeted nature of cancer therapies, cardiac and vascular side effects may additionally provide insights into the basic biology of vascular disease. We herein provide the example of tyrosine kinase inhibitors utilized in chronic myelogenous leukemia to illustrate this medical transformation. We describe the vascular considerations for the clinical care of chronic myelogenous leukemia patients as well as the emerging literature on mechanisms of toxicities of the individual tyrosine kinase inhibitors. We additionally postulate that basic insights into toxicities of novel cancer therapies may serve as a new platform for investigation in vascular biology and a new translational research opportunity in vascular medicine.

    Original languageEnglish (US)
    Pages (from-to)301-308
    Number of pages8
    JournalArteriosclerosis, thrombosis, and vascular biology
    Volume40
    Issue number2
    DOIs
    StatePublished - Feb 1 2020

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    Keywords

    • leukemia, myelogenous, chronic, BCR-ABL positive
    • patient care
    • peripheral arterial disease
    • prognosis
    • tyrosine kinase

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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