Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Xuan Qin, Brian Poon, Justin Kwong, Denver Niles, Byron Z. Schmidt, Lakshmi Rajagopal, Soren Gantt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)LC gene not previously described in S. aureus. The native plasmids carrying vga(A)LC were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume38
Issue number1
DOIs
StatePublished - Jul 2011
Externally publishedYes

Keywords

  • Clindamycin
  • Efflux pump
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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