Two mammalian genes transcribed from opposite strands of the same DNA locus

John P. Adelman, Chris T. Bond, James Douglass, Edward Herbert

Research output: Contribution to journalArticle

151 Scopus citations

Abstract

This report describes the characterization of a genomic locus in the rat that encodes overlapping genes occupying both strands of the same piece of A. One gene (strand) encodes gonadotropin-releasing hormone (GnRH). A second gene, SH, is transcribed from the other DNA strand to produce RNA ofundefined function. The RNAs transcribed from each DNA strand are spliced and polyadenylated, and share significant exon domains. GnRH is expressed in the central nervous system while SH transcripts are present in the heart. Thus, the genome of a mammalian organism encodes two distinct genes by using both strands of the same DNA.

Original languageEnglish (US)
Pages (from-to)1514-1517
Number of pages4
JournalScience
Volume235
Issue number4795
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • General

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