Two mammalian genes transcribed from opposite strands of the same DNA locus

John Adelman, Chris T. Bond, James Douglass, Edward Herbert

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

This report describes the characterization of a genomic locus in the rat that encodes overlapping genes occupying both strands of the same piece of A. One gene (strand) encodes gonadotropin-releasing hormone (GnRH). A second gene, SH, is transcribed from the other DNA strand to produce RNA ofundefined function. The RNAs transcribed from each DNA strand are spliced and polyadenylated, and share significant exon domains. GnRH is expressed in the central nervous system while SH transcripts are present in the heart. Thus, the genome of a mammalian organism encodes two distinct genes by using both strands of the same DNA.

Original languageEnglish (US)
Pages (from-to)1514-1517
Number of pages4
JournalScience
Volume235
Issue number4795
StatePublished - 1987

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Gonadotropin-Releasing Hormone
DNA
Overlapping Genes
RNA
Genes
Exons
Central Nervous System
Genome

ASJC Scopus subject areas

  • General

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Adelman, J., Bond, C. T., Douglass, J., & Herbert, E. (1987). Two mammalian genes transcribed from opposite strands of the same DNA locus. Science, 235(4795), 1514-1517.

Two mammalian genes transcribed from opposite strands of the same DNA locus. / Adelman, John; Bond, Chris T.; Douglass, James; Herbert, Edward.

In: Science, Vol. 235, No. 4795, 1987, p. 1514-1517.

Research output: Contribution to journalArticle

Adelman, J, Bond, CT, Douglass, J & Herbert, E 1987, 'Two mammalian genes transcribed from opposite strands of the same DNA locus', Science, vol. 235, no. 4795, pp. 1514-1517.
Adelman J, Bond CT, Douglass J, Herbert E. Two mammalian genes transcribed from opposite strands of the same DNA locus. Science. 1987;235(4795):1514-1517.
Adelman, John ; Bond, Chris T. ; Douglass, James ; Herbert, Edward. / Two mammalian genes transcribed from opposite strands of the same DNA locus. In: Science. 1987 ; Vol. 235, No. 4795. pp. 1514-1517.
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