Two Insulin Genes Are Present in the Salmon Genome

V. Kavsan, A. Koval, O. Petrenko, Charles Roberts, D. Leroith

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

According to the accepted hypothesis, polyploid evolution is necessary to achieve meaningful gene duplication. Some fish, namely those belonging to the suborder Salmonidae, appear to be autotetraploid species that probably originated from a diploid ancestor relatively recently and that appear to be progressing toward diploidization to various degrees. The Pacific chum salmon (Oncorhynchus keta) has almost completed this process of diploidization. Thus, with regard to practically any gene product, theory predicts a freshly diploidized, autotetraploid species to possess twice the number of gene loci as diploid animals. Here we show that the chum salmon genome contains two nonallelic insulin genes that are both expressed in chum salmon Brockman bodies. Nucleotide sequence analysis reveals structural diversification of this pair of duplicated genes.

Original languageEnglish (US)
Pages (from-to)1373-1378
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume191
Issue number3
DOIs
StatePublished - Mar 31 1993
Externally publishedYes

Fingerprint

Oncorhynchus keta
Salmon
Genes
Genome
Insulin
Diploidy
Salmonidae
Polyploidy
Gene Duplication
Sequence Analysis
Fishes
Structural analysis
Fish
Animals
Nucleotides

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

Two Insulin Genes Are Present in the Salmon Genome. / Kavsan, V.; Koval, A.; Petrenko, O.; Roberts, Charles; Leroith, D.

In: Biochemical and Biophysical Research Communications, Vol. 191, No. 3, 31.03.1993, p. 1373-1378.

Research output: Contribution to journalArticle

Kavsan, V. ; Koval, A. ; Petrenko, O. ; Roberts, Charles ; Leroith, D. / Two Insulin Genes Are Present in the Salmon Genome. In: Biochemical and Biophysical Research Communications. 1993 ; Vol. 191, No. 3. pp. 1373-1378.
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