Twin-tube endografts for aortic aneurysms: An experimental feasibility study

Shoiji Sakaguchi, Barry Uchida, Hans A. Timmermans, Dusan Pavcnik, Yukimasa Sakai, Frederick Keller, Josef Rosch, Qiang (Michael) Yin, Kimihiko Kichikawa, Hideo Uchida

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

PURPOSE: To explore feasibility of twin-tube endografts (TTEGs) for treatment of abdominal aortic aneurysm (AAA). MATERIALS AND METHODS: AAAs were created in six dogs by overdilation of Palmaz stents. TTEGs made of seven 9.5-mm-diameter Gianturco Rosch Z (GRZ) stents and covered with PTFE were deployed simultaneously from both femoral arteries through 10-F sheaths to exclude the AAA. Follow-up aortography was performed immediately and at 2, 4, and 8 weeks. Two dogs were killed at 4 weeks and four were killed at 8 weeks. Gross and histologic examinations were performed. RESULTS: AAA creation and TTEG placement were successful in all six dogs. TTEGs completely excluded AAAs in five dogs. Minor temporary perigraft leak was seen in one dog immediately after stent placement. Four dogs had TTEGs patent to termination at 8 weeks. In two dogs with oversized TTEGs, one of the twin endografts occluded at 2 weeks. At autopsy, TTEGs were formed in semicircular shape and histology did not show any significant inflammatory reaction. CONCLUSION: TTEGs show promise for treatment of AAA, with the potential of reducing the introductory sheath size. Further experimental studies, particularly with TTEGs extended into iliac arteries, are warranted.

Original languageEnglish (US)
Pages (from-to)1092-1098
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume10
Issue number8
StatePublished - 1999

Fingerprint

Aortic Aneurysm
Feasibility Studies
Dogs
Abdominal Aortic Aneurysm
Stents
Endoleak
Aortography
Iliac Artery
Polytetrafluoroethylene
Femoral Artery
Autopsy
Histology
Therapeutics

Keywords

  • Aneurysm; aortic
  • Interventional procedure, experimental
  • Stents and prostheses

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sakaguchi, S., Uchida, B., Timmermans, H. A., Pavcnik, D., Sakai, Y., Keller, F., ... Uchida, H. (1999). Twin-tube endografts for aortic aneurysms: An experimental feasibility study. Journal of Vascular and Interventional Radiology, 10(8), 1092-1098.

Twin-tube endografts for aortic aneurysms : An experimental feasibility study. / Sakaguchi, Shoiji; Uchida, Barry; Timmermans, Hans A.; Pavcnik, Dusan; Sakai, Yukimasa; Keller, Frederick; Rosch, Josef; Yin, Qiang (Michael); Kichikawa, Kimihiko; Uchida, Hideo.

In: Journal of Vascular and Interventional Radiology, Vol. 10, No. 8, 1999, p. 1092-1098.

Research output: Contribution to journalArticle

Sakaguchi, S, Uchida, B, Timmermans, HA, Pavcnik, D, Sakai, Y, Keller, F, Rosch, J, Yin, QM, Kichikawa, K & Uchida, H 1999, 'Twin-tube endografts for aortic aneurysms: An experimental feasibility study', Journal of Vascular and Interventional Radiology, vol. 10, no. 8, pp. 1092-1098.
Sakaguchi, Shoiji ; Uchida, Barry ; Timmermans, Hans A. ; Pavcnik, Dusan ; Sakai, Yukimasa ; Keller, Frederick ; Rosch, Josef ; Yin, Qiang (Michael) ; Kichikawa, Kimihiko ; Uchida, Hideo. / Twin-tube endografts for aortic aneurysms : An experimental feasibility study. In: Journal of Vascular and Interventional Radiology. 1999 ; Vol. 10, No. 8. pp. 1092-1098.
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