Turning the tide in myelodysplastic/myeloproliferative neoplasms

Michael W.N. Deininger, Jeffrey Tyner, Eric Solary

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive myeloid malignancies recognized as a distinct category owing to their unique combination of dysplastic and proliferative features. Although current classification schemes still emphasize morphology and exclusionary criteria, disease-defining somatic mutations and/or germline predisposition alleles are increasingly incorporated into diagnostic algorithms. The developing picture suggests that phenotypes are driven mostly by epigenetic mechanisms that reflect a complex interplay between genotype, physiological processes such as ageing and interactions between malignant haematopoietic cells and the stromal microenvironment of the bone marrow. Despite the rapid accumulation of genetic knowledge, therapies have remained nonspecific and largely inefficient. In this Review, we discuss the pathogenesis of MDS/MPN, focusing on the relationship between genotype and phenotype and the molecular underpinnings of epigenetic dysregulation. Starting with the limitations of current therapies, we also explore how the available mechanistic data may be harnessed to inform strategies to develop rational and more effective treatments, and which gaps in our knowledge need to be filled to translate biological understanding into clinical progress.

Original languageEnglish (US)
Pages (from-to)425-440
Number of pages16
JournalNature Reviews Cancer
Volume17
Issue number7
DOIs
StatePublished - Jul 1 2017

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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