Tunability and noise dependence in differentiation dynamics

Gürol M. Süel, Rajan P. Kulkarni, Jonathan Dworkin, Jordi Garcia-Ojalvo, Michael B. Elowitz

Research output: Contribution to journalArticlepeer-review

339 Scopus citations

Abstract

The dynamic process of differentiation depends on the architecture, quantitative parameters, and noise of underlying genetic circuits. However, it remains unclear how these elements combine to control cellular behavior. We analyzed the probabilistic and transient differentiation of Bacillus subtilis cells into the state of competence. A few key parameters independently tuned the frequency of initiation and the duration of competence episodes and allowed the circuit to access different dynamic regimes, including oscillation. Altering circuit architecture showed that the duration of competence events can be made more precise. We used an experimental method to reduce global cellular noise and showed that noise levels are correlated with frequency of differentiation events. Together, the data reveal a noise-dependent circuit that is remarkably resilient and tunable in terms of its dynamic behavior.

Original languageEnglish (US)
Pages (from-to)1716-1719
Number of pages4
JournalScience
Volume315
Issue number5819
DOIs
StatePublished - Mar 23 2007
Externally publishedYes

ASJC Scopus subject areas

  • General

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