Tumor growth, weight loss and cytokines in SCID mice

Susan Murray, Kathleen Schell, Donna O. McCarthy, Mark R. Albertini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

It has been proposed that immunoregulatory cytokines play a role in the onset and development of cancer cachexia, although evidence supporting this theory remains inconclusive. In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. We conclude that increased cytokine expression is associated with weight loss in tumor-bearing SCID mice, and immune activation for cytokine expression does not require the presence of T or B cells.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalCancer Letters
Volume111
Issue number1-2
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

SCID Mice
Tumor Burden
Weight Loss
Cytokines
Growth
Neoplasms
Spleen
Experimental Liver Neoplasms
Cachexia
Tumor Cell Line
Interleukin-1
Sarcoma
Interleukin-6
B-Lymphocytes
Tumor Necrosis Factor-alpha
T-Lymphocytes

Keywords

  • Cytokines
  • SCID/scid mice
  • Tumor growth
  • Weight loss

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Murray, S., Schell, K., McCarthy, D. O., & Albertini, M. R. (1997). Tumor growth, weight loss and cytokines in SCID mice. Cancer Letters, 111(1-2), 111-115. https://doi.org/10.1016/S0304-3835(96)04519-3

Tumor growth, weight loss and cytokines in SCID mice. / Murray, Susan; Schell, Kathleen; McCarthy, Donna O.; Albertini, Mark R.

In: Cancer Letters, Vol. 111, No. 1-2, 01.01.1997, p. 111-115.

Research output: Contribution to journalArticle

Murray, S, Schell, K, McCarthy, DO & Albertini, MR 1997, 'Tumor growth, weight loss and cytokines in SCID mice', Cancer Letters, vol. 111, no. 1-2, pp. 111-115. https://doi.org/10.1016/S0304-3835(96)04519-3
Murray S, Schell K, McCarthy DO, Albertini MR. Tumor growth, weight loss and cytokines in SCID mice. Cancer Letters. 1997 Jan 1;111(1-2):111-115. https://doi.org/10.1016/S0304-3835(96)04519-3
Murray, Susan ; Schell, Kathleen ; McCarthy, Donna O. ; Albertini, Mark R. / Tumor growth, weight loss and cytokines in SCID mice. In: Cancer Letters. 1997 ; Vol. 111, No. 1-2. pp. 111-115.
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