Tumor-associated macrophages press the angiogenic switch in breast cancer

Elaine Lin, Jeffrey W. Pollard

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

Original languageEnglish (US)
Pages (from-to)5064-5066
Number of pages3
JournalCancer Research
Volume67
Issue number11
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Fingerprint

Macrophages
Breast Neoplasms
Neoplasms
Microvessels

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tumor-associated macrophages press the angiogenic switch in breast cancer. / Lin, Elaine; Pollard, Jeffrey W.

In: Cancer Research, Vol. 67, No. 11, 01.06.2007, p. 5064-5066.

Research output: Contribution to journalArticle

Lin, Elaine ; Pollard, Jeffrey W. / Tumor-associated macrophages press the angiogenic switch in breast cancer. In: Cancer Research. 2007 ; Vol. 67, No. 11. pp. 5064-5066.
@article{8aba533ee8204b0294fb86ad321c038e,
title = "Tumor-associated macrophages press the angiogenic switch in breast cancer",
abstract = "The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.",
author = "Elaine Lin and Pollard, {Jeffrey W.}",
year = "2007",
month = "6",
day = "1",
doi = "10.1158/0008-5472.CAN-07-0912",
language = "English (US)",
volume = "67",
pages = "5064--5066",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

TY - JOUR

T1 - Tumor-associated macrophages press the angiogenic switch in breast cancer

AU - Lin, Elaine

AU - Pollard, Jeffrey W.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

AB - The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

UR - http://www.scopus.com/inward/record.url?scp=34347226359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347226359&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-07-0912

DO - 10.1158/0008-5472.CAN-07-0912

M3 - Article

VL - 67

SP - 5064

EP - 5066

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 11

ER -