Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
Original language | English (US) |
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Pages (from-to) | 5064-5066 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 67 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research