Tumefactive Demyelination in Multiple Sclerosis: Clinical Presentation, Pathophysiology and Treatment Options

Meredith C. Frederick, Michelle H. Cameron

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumefactive demyelinating lesions are caused by a heterogeneous group of central nervous system (CNS) idiopathic inflammatory demyelinating diseases. Tumefactive demyelinating lesions are uncommon and present a diagnostic challenge because they can be difficult to distinguish from tumors. This chapter reviews the clinical presentation, radiographic features, pathophysiology, prognosis, and management of patients with tumefactive demyelinating lesions, with specific attention to how these relate to typical multiple sclerosis. The rare variants of multiple sclerosis, including Schilder’s disease, Marburg acute multiple sclerosis, and Balo’s concentric sclerosis, are also discussed. Tumefactive presentations of neuromyelitis optic, acute disseminated encephalomyelitis (ADEM), and acute hemorrhagic leukoencephalitis are not covered in this chapter.

Original languageEnglish (US)
Title of host publicationNeuroinflammation
PublisherElsevier
Pages261-275
Number of pages15
ISBN (Electronic)9780128117095
ISBN (Print)9780128117248
DOIs
StatePublished - Jan 1 2018

Keywords

  • Balo concentric sclerosis
  • Marburg acute multiple sclerosis
  • Schilder’s disease
  • Tumefactive demyelination
  • multiple sclerosis
  • myelinoclastic diffuse sclerosis
  • tumefactive multiple sclerosis

ASJC Scopus subject areas

  • General Medicine

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