Abstract
We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1518-1521 |
| Number of pages | 4 |
| Journal | Clinical Infectious Diseases |
| Volume | 45 |
| Issue number | 11 |
| DOIs | |
| State | Published - Dec 1 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Microbiology (medical)
- Infectious Diseases
Cite this
Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. / Brinkhof, Martin W G; Egger, Matthias; Boulle, Andrew; May, Margaret; Hosseinipour, Mina; Sprinz, Eduardo; Braitstein, Paula; Dabis, François; Reiss, Peter; Bangsberg, David; Rickenbach, Martin; Miro, Jose M.; Myer, Landon; Mocroft, Amanda; Nash, Denis; Keiser, Olivia; Pascoe, Margaret; Van Der Borght, Stefaan; Schechter, Mauro; Brinkhof, Martin.
In: Clinical Infectious Diseases, Vol. 45, No. 11, 01.12.2007, p. 1518-1521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries
AU - Brinkhof, Martin W G
AU - Egger, Matthias
AU - Boulle, Andrew
AU - May, Margaret
AU - Hosseinipour, Mina
AU - Sprinz, Eduardo
AU - Braitstein, Paula
AU - Dabis, François
AU - Reiss, Peter
AU - Bangsberg, David
AU - Rickenbach, Martin
AU - Miro, Jose M.
AU - Myer, Landon
AU - Mocroft, Amanda
AU - Nash, Denis
AU - Keiser, Olivia
AU - Pascoe, Margaret
AU - Van Der Borght, Stefaan
AU - Schechter, Mauro
AU - Brinkhof, Martin
PY - 2007/12/1
Y1 - 2007/12/1
N2 - We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.
AB - We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.
UR - http://www.scopus.com/inward/record.url?scp=38449116968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38449116968&partnerID=8YFLogxK
U2 - 10.1086/522986
DO - 10.1086/522986
M3 - Article
C2 - 17990236
AN - SCOPUS:38449116968
VL - 45
SP - 1518
EP - 1521
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 11
ER -