Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries

Martin W G Brinkhof, Matthias Egger, Andrew Boulle, Margaret May, Mina Hosseinipour, Eduardo Sprinz, Paula Braitstein, François Dabis, Peter Reiss, David Bangsberg, Martin Rickenbach, Jose M. Miro, Landon Myer, Amanda Mocroft, Denis Nash, Olivia Keiser, Margaret Pascoe, Stefaan Van Der Borght, Mauro Schechter, Martin Brinkhof

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

Original languageEnglish (US)
Pages (from-to)1518-1521
Number of pages4
JournalClinical Infectious Diseases
Volume45
Issue number11
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Tuberculosis
Highly Active Antiretroviral Therapy
Incidence
Confidence Intervals
Therapeutics
CD4 Lymphocyte Count

ASJC Scopus subject areas

  • Medicine(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Brinkhof, M. W. G., Egger, M., Boulle, A., May, M., Hosseinipour, M., Sprinz, E., ... Brinkhof, M. (2007). Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. Clinical Infectious Diseases, 45(11), 1518-1521. https://doi.org/10.1086/522986

Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. / Brinkhof, Martin W G; Egger, Matthias; Boulle, Andrew; May, Margaret; Hosseinipour, Mina; Sprinz, Eduardo; Braitstein, Paula; Dabis, François; Reiss, Peter; Bangsberg, David; Rickenbach, Martin; Miro, Jose M.; Myer, Landon; Mocroft, Amanda; Nash, Denis; Keiser, Olivia; Pascoe, Margaret; Van Der Borght, Stefaan; Schechter, Mauro; Brinkhof, Martin.

In: Clinical Infectious Diseases, Vol. 45, No. 11, 01.12.2007, p. 1518-1521.

Research output: Contribution to journalArticle

Brinkhof, MWG, Egger, M, Boulle, A, May, M, Hosseinipour, M, Sprinz, E, Braitstein, P, Dabis, F, Reiss, P, Bangsberg, D, Rickenbach, M, Miro, JM, Myer, L, Mocroft, A, Nash, D, Keiser, O, Pascoe, M, Van Der Borght, S, Schechter, M & Brinkhof, M 2007, 'Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries', Clinical Infectious Diseases, vol. 45, no. 11, pp. 1518-1521. https://doi.org/10.1086/522986
Brinkhof MWG, Egger M, Boulle A, May M, Hosseinipour M, Sprinz E et al. Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. Clinical Infectious Diseases. 2007 Dec 1;45(11):1518-1521. https://doi.org/10.1086/522986
Brinkhof, Martin W G ; Egger, Matthias ; Boulle, Andrew ; May, Margaret ; Hosseinipour, Mina ; Sprinz, Eduardo ; Braitstein, Paula ; Dabis, François ; Reiss, Peter ; Bangsberg, David ; Rickenbach, Martin ; Miro, Jose M. ; Myer, Landon ; Mocroft, Amanda ; Nash, Denis ; Keiser, Olivia ; Pascoe, Margaret ; Van Der Borght, Stefaan ; Schechter, Mauro ; Brinkhof, Martin. / Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. In: Clinical Infectious Diseases. 2007 ; Vol. 45, No. 11. pp. 1518-1521.
@article{1c5e4ed8d24d4a03b741d470ca48220d,
title = "Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries",
abstract = "We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95{\%} confidence interval, 0.36-0.64) in low-income countries and 0.36 (95{\%} confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.",
author = "Brinkhof, {Martin W G} and Matthias Egger and Andrew Boulle and Margaret May and Mina Hosseinipour and Eduardo Sprinz and Paula Braitstein and Fran{\cc}ois Dabis and Peter Reiss and David Bangsberg and Martin Rickenbach and Miro, {Jose M.} and Landon Myer and Amanda Mocroft and Denis Nash and Olivia Keiser and Margaret Pascoe and {Van Der Borght}, Stefaan and Mauro Schechter and Martin Brinkhof",
year = "2007",
month = "12",
day = "1",
doi = "10.1086/522986",
language = "English (US)",
volume = "45",
pages = "1518--1521",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries

AU - Brinkhof, Martin W G

AU - Egger, Matthias

AU - Boulle, Andrew

AU - May, Margaret

AU - Hosseinipour, Mina

AU - Sprinz, Eduardo

AU - Braitstein, Paula

AU - Dabis, François

AU - Reiss, Peter

AU - Bangsberg, David

AU - Rickenbach, Martin

AU - Miro, Jose M.

AU - Myer, Landon

AU - Mocroft, Amanda

AU - Nash, Denis

AU - Keiser, Olivia

AU - Pascoe, Margaret

AU - Van Der Borght, Stefaan

AU - Schechter, Mauro

AU - Brinkhof, Martin

PY - 2007/12/1

Y1 - 2007/12/1

N2 - We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

AB - We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

UR - http://www.scopus.com/inward/record.url?scp=38449116968&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449116968&partnerID=8YFLogxK

U2 - 10.1086/522986

DO - 10.1086/522986

M3 - Article

C2 - 17990236

AN - SCOPUS:38449116968

VL - 45

SP - 1518

EP - 1521

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 11

ER -