TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion

Byung Ju Lee, Gyeong J. Cho, Robert B. Norgren, Marie Pierre Junier, Diane F. Hill, Veronica Tapia, Maria E. Costa, Sergio Ojeda

    Research output: Contribution to journalArticle

    88 Citations (Scopus)

    Abstract

    TTF-1 is a member of the Nkx family of homeodomain genes required for morphogenesis of the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating differentiated hypothalamic functions is not known. We now report that postnatal hypothalamic TTF-1 expression is developmentally regulated and associated with the neuroendocrine process of female sexual development. Lesions of the hypothalamus that cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site. In intact animals, hypothalamic TTF-1 mRNA content also increases transiently, preceding the initiation of puberty. Postnatal expression of the TTF-1 gone was limited to subsets of hypothalamic neurons, including LHRH neurons, which control sexual maturation, and proproenkephalinergic neurons of the lateroventromedial nucleus of the basal hypothamamus, which restrain sexual maturation and facilitate reproductive behavior. TTF-1 mRNA was also detected in astrocytes of the median eminence and ependymal/subependymal cells of the third ventricle, where it colocalized with erbB-2, a receptor involved in facilitating sexual development. TTF-1 binds to and transactivates the erbB-2 and LHRH promoters, but represses transcription of the preproenkephalin gene. The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrine reproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.

    Original languageEnglish (US)
    Pages (from-to)107-126
    Number of pages20
    JournalMolecular and Cellular Neuroscience
    Volume17
    Issue number1
    DOIs
    StatePublished - 2001

    Fingerprint

    Morphogenesis
    Puberty
    Sexual Maturation
    Sexual Development
    Brain
    Neurons
    Gonadotropin-Releasing Hormone
    Genes
    Hypothalamus
    ErbB-2 Receptor
    Reproductive Behavior
    Messenger RNA
    Median Eminence
    Third Ventricle
    Basal Ganglia
    Astrocytes
    Gene Expression

    ASJC Scopus subject areas

    • Molecular Biology
    • Cellular and Molecular Neuroscience
    • Developmental Neuroscience

    Cite this

    TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. / Lee, Byung Ju; Cho, Gyeong J.; Norgren, Robert B.; Junier, Marie Pierre; Hill, Diane F.; Tapia, Veronica; Costa, Maria E.; Ojeda, Sergio.

    In: Molecular and Cellular Neuroscience, Vol. 17, No. 1, 2001, p. 107-126.

    Research output: Contribution to journalArticle

    Lee, Byung Ju ; Cho, Gyeong J. ; Norgren, Robert B. ; Junier, Marie Pierre ; Hill, Diane F. ; Tapia, Veronica ; Costa, Maria E. ; Ojeda, Sergio. / TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. In: Molecular and Cellular Neuroscience. 2001 ; Vol. 17, No. 1. pp. 107-126.
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    abstract = "TTF-1 is a member of the Nkx family of homeodomain genes required for morphogenesis of the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating differentiated hypothalamic functions is not known. We now report that postnatal hypothalamic TTF-1 expression is developmentally regulated and associated with the neuroendocrine process of female sexual development. Lesions of the hypothalamus that cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site. In intact animals, hypothalamic TTF-1 mRNA content also increases transiently, preceding the initiation of puberty. Postnatal expression of the TTF-1 gone was limited to subsets of hypothalamic neurons, including LHRH neurons, which control sexual maturation, and proproenkephalinergic neurons of the lateroventromedial nucleus of the basal hypothamamus, which restrain sexual maturation and facilitate reproductive behavior. TTF-1 mRNA was also detected in astrocytes of the median eminence and ependymal/subependymal cells of the third ventricle, where it colocalized with erbB-2, a receptor involved in facilitating sexual development. TTF-1 binds to and transactivates the erbB-2 and LHRH promoters, but represses transcription of the preproenkephalin gene. The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrine reproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.",
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