TSLP signaling pathway map: A platform for analysis of TSLP-mediated signaling

Jun Zhong, Jyoti Sharma, Rajesh Raju, Shyam Mohan Palapetta, T. S.Keshava Prasad, Tai Chung Huang, Akinori Yoda, Jeffrey W. Tyner, Diederik Van Bodegom, David M. Weinstock, Steven F. Ziegler, Akhilesh Pandey

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and inthe differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling.

Original languageEnglish (US)
JournalDatabase
Volume2014
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Zhong, J., Sharma, J., Raju, R., Palapetta, S. M., Prasad, T. S. K., Huang, T. C., Yoda, A., Tyner, J. W., Van Bodegom, D., Weinstock, D. M., Ziegler, S. F., & Pandey, A. (2014). TSLP signaling pathway map: A platform for analysis of TSLP-mediated signaling. Database, 2014. https://doi.org/10.1093/database/bau007