TSLP signaling pathway map

a platform for analysis of TSLP-mediated signaling.

Jun Zhong, Jyoti Sharma, Rajesh Raju, Shyam Mohan Palapetta, T. S Keshava Prasad, Tai Chung Huang, Akinori Yoda, Jeffrey Tyner, Diederik van Bodegom, David M. Weinstock, Steven F. Ziegler, Akhilesh Pandey

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24.

Original languageEnglish (US)
JournalDatabase : the journal of biological databases and curation
Volume2014
DOIs
StatePublished - 2014

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receptors
cytokines
T-lymphocytes
interleukin-7
Regulatory T-Lymphocytes
Cells
lymphocytic leukemia
atopic dermatitis
inflammatory bowel disease
phosphatidylinositol 3-kinase
Signal transduction
asthma
mast cells
dendritic cells
T-cells
thymic stromal lymphopoietin
human diseases
Interleukin-7 Receptors
Cataloging
B-lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

TSLP signaling pathway map : a platform for analysis of TSLP-mediated signaling. / Zhong, Jun; Sharma, Jyoti; Raju, Rajesh; Palapetta, Shyam Mohan; Prasad, T. S Keshava; Huang, Tai Chung; Yoda, Akinori; Tyner, Jeffrey; van Bodegom, Diederik; Weinstock, David M.; Ziegler, Steven F.; Pandey, Akhilesh.

In: Database : the journal of biological databases and curation, Vol. 2014, 2014.

Research output: Contribution to journalArticle

Zhong, J, Sharma, J, Raju, R, Palapetta, SM, Prasad, TSK, Huang, TC, Yoda, A, Tyner, J, van Bodegom, D, Weinstock, DM, Ziegler, SF & Pandey, A 2014, 'TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.', Database : the journal of biological databases and curation, vol. 2014. https://doi.org/10.1093/database/bau007
Zhong, Jun ; Sharma, Jyoti ; Raju, Rajesh ; Palapetta, Shyam Mohan ; Prasad, T. S Keshava ; Huang, Tai Chung ; Yoda, Akinori ; Tyner, Jeffrey ; van Bodegom, Diederik ; Weinstock, David M. ; Ziegler, Steven F. ; Pandey, Akhilesh. / TSLP signaling pathway map : a platform for analysis of TSLP-mediated signaling. In: Database : the journal of biological databases and curation. 2014 ; Vol. 2014.
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abstract = "Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24.",
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AU - Zhong, Jun

AU - Sharma, Jyoti

AU - Raju, Rajesh

AU - Palapetta, Shyam Mohan

AU - Prasad, T. S Keshava

AU - Huang, Tai Chung

AU - Yoda, Akinori

AU - Tyner, Jeffrey

AU - van Bodegom, Diederik

AU - Weinstock, David M.

AU - Ziegler, Steven F.

AU - Pandey, Akhilesh

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