TRPV4 and the mammalian kidney

Research output: Contribution to journalArticle

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Abstract

Transient receptor potential vanilloid 4 (TRPV4) was identified as the mammalian homologue of the Caenorhabditis elegans osmosensory channel protein, OSM-9. In mammals, TRPV4 is activated by a variety of stimuli including thermal stress, fatty acid metabolites, and hypotonicity. Two distinct mechanisms have been described through which TRPV4 may be activated by hypotonicity: one involves the Src family of nonreceptor protein tyrosine kinases, whereas a second is mediated via arachidonic acid metabolites. TRPV4 likely plays a role in systemic osmoregulation; accordingly, it is expressed in the blood-brain barrier-deficient osmosensory nuclei of the hypothalamus. TRPV4 is also abundantly expressed in the kidney, and its precisely demarcated distribution along the kidney tubule permits speculation about a physiological role in this tissue. TRPV4-expressing and TRPV4-negative tubule segments co-exist at all levels of the kidney, from the cortex through the inner medulla. It is conceivable that basolaterally expressed TRPV4 transmits signals arising in the interstitium (e.g, changing tonicity) to more-distal tubule segments where "fine-tuning" of the incipient urine takes place.

Original languageEnglish (US)
Pages (from-to)168-175
Number of pages8
JournalPflugers Archiv European Journal of Physiology
Volume451
Issue number1
DOIs
StatePublished - Oct 2005

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TRPV Cation Channels
Kidney
Metabolites
Kidney Tubules
Osmoregulation
Kidney Cortex
Mammals
Caenorhabditis elegans
Blood-Brain Barrier
Arachidonic Acid
Thermal stress
Protein-Tyrosine Kinases
Hypothalamus
Fatty Acids
Tuning
Hot Temperature
Urine
Tissue

ASJC Scopus subject areas

  • Physiology

Cite this

TRPV4 and the mammalian kidney. / Cohen, David.

In: Pflugers Archiv European Journal of Physiology, Vol. 451, No. 1, 10.2005, p. 168-175.

Research output: Contribution to journalArticle

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