TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus

James H. Peters, Stuart J. McDougall, Jessica A. Fawley, Michael Andresen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

TRPV1 receptors are expressed on most but not all central terminals of cranial visceral afferents in the caudal solitary tract nucleus (NTS). TRPV1 is associated with unmyelinated C-fiber afferents. Both TRPV1+ and TRPV1- afferents enter NTS but their precise organization remains poorly understood. In horizontal brainstem slices, we activated solitary tract (ST) afferents and recorded ST-evoked glutamatergic excitatory synaptic currents (ST-EPSCs) under whole cell voltage clamp conditions from neurons of the medial subnucleus. Electrical shocks to the ST produced fixed latency EPSCs (jitter

Original languageEnglish (US)
Article numbere25015
JournalPLoS One
Volume6
Issue number9
DOIs
StatePublished - Sep 20 2011

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Visceral Afferents
Unmyelinated Nerve Fibers
Solitary Nucleus
Clamping devices
brain stem
Jitter
Brain Stem
Neurons
Rats
Shock
neurons
receptors
Fibers
rats
Electric potential
cells
TRPV1 receptor

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus. / Peters, James H.; McDougall, Stuart J.; Fawley, Jessica A.; Andresen, Michael.

In: PLoS One, Vol. 6, No. 9, e25015, 20.09.2011.

Research output: Contribution to journalArticle

Peters, James H. ; McDougall, Stuart J. ; Fawley, Jessica A. ; Andresen, Michael. / TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus. In: PLoS One. 2011 ; Vol. 6, No. 9.
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