TRPCing around the hypothalamus

Research output: Contribution to journalArticle

Abstract

All of the canonical transient receptor potential channels (TRPC) with the exception of TRPC 2 are expressed in hypothalamic neurons and are involved in multiple homeostatic functions. Although the metabotropic glutamate receptors have been shown to be coupled to TRPC channel activation in cortical and sub-cortical brain regions, in the hypothalamus multiple amine and peptidergic G protein-coupled receptors (GPCRs) and growth factor/cytokine receptors are linked to activation of TRPC channels that are vital for reproduction, temperature regulation, arousal and energy homeostasis. In addition to the neurotransmitters, circulating hormones like insulin and leptin through their cognate receptors activate TRPC channels in POMC neurons. Many of the post-synaptic effects of the neurotransmitters and hormones are regulated in different physiological states by expression of TRPC channels in the post-synaptic neurons. Therefore, TRPC channels are key targets not only for neurotransmitters but circulating hormones in their vital role to control multiple hypothalamic functions, which is the focus of this review.

Original languageEnglish (US)
JournalFrontiers in Neuroendocrinology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Transient Receptor Potential Channels
Hypothalamus
Neurotransmitter Agents
Hormones
Neurons
Pro-Opiomelanocortin
Metabotropic Glutamate Receptors
Cytokine Receptors
Growth Factor Receptors
G-Protein-Coupled Receptors
Leptin
Arousal
Amines
Reproduction
Homeostasis
Insulin
Temperature
Brain

Keywords

  • 17β-estradiol
  • GnRH
  • Insulin
  • Kisspeptin
  • Leptin
  • Neurokinin B
  • Orexin
  • POMC
  • TRPC channels

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Cite this

TRPCing around the hypothalamus. / Kelly, Martin; Qiu, Jian; Ronnekleiv, Oline.

In: Frontiers in Neuroendocrinology, 01.01.2018.

Research output: Contribution to journalArticle

@article{ad227600574c4f889aa7c4852d9558ff,
title = "TRPCing around the hypothalamus",
abstract = "All of the canonical transient receptor potential channels (TRPC) with the exception of TRPC 2 are expressed in hypothalamic neurons and are involved in multiple homeostatic functions. Although the metabotropic glutamate receptors have been shown to be coupled to TRPC channel activation in cortical and sub-cortical brain regions, in the hypothalamus multiple amine and peptidergic G protein-coupled receptors (GPCRs) and growth factor/cytokine receptors are linked to activation of TRPC channels that are vital for reproduction, temperature regulation, arousal and energy homeostasis. In addition to the neurotransmitters, circulating hormones like insulin and leptin through their cognate receptors activate TRPC channels in POMC neurons. Many of the post-synaptic effects of the neurotransmitters and hormones are regulated in different physiological states by expression of TRPC channels in the post-synaptic neurons. Therefore, TRPC channels are key targets not only for neurotransmitters but circulating hormones in their vital role to control multiple hypothalamic functions, which is the focus of this review.",
keywords = "17β-estradiol, GnRH, Insulin, Kisspeptin, Leptin, Neurokinin B, Orexin, POMC, TRPC channels",
author = "Martin Kelly and Jian Qiu and Oline Ronnekleiv",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.yfrne.2018.05.004",
language = "English (US)",
journal = "Frontiers in Neuroendocrinology",
issn = "0091-3022",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - TRPCing around the hypothalamus

AU - Kelly, Martin

AU - Qiu, Jian

AU - Ronnekleiv, Oline

PY - 2018/1/1

Y1 - 2018/1/1

N2 - All of the canonical transient receptor potential channels (TRPC) with the exception of TRPC 2 are expressed in hypothalamic neurons and are involved in multiple homeostatic functions. Although the metabotropic glutamate receptors have been shown to be coupled to TRPC channel activation in cortical and sub-cortical brain regions, in the hypothalamus multiple amine and peptidergic G protein-coupled receptors (GPCRs) and growth factor/cytokine receptors are linked to activation of TRPC channels that are vital for reproduction, temperature regulation, arousal and energy homeostasis. In addition to the neurotransmitters, circulating hormones like insulin and leptin through their cognate receptors activate TRPC channels in POMC neurons. Many of the post-synaptic effects of the neurotransmitters and hormones are regulated in different physiological states by expression of TRPC channels in the post-synaptic neurons. Therefore, TRPC channels are key targets not only for neurotransmitters but circulating hormones in their vital role to control multiple hypothalamic functions, which is the focus of this review.

AB - All of the canonical transient receptor potential channels (TRPC) with the exception of TRPC 2 are expressed in hypothalamic neurons and are involved in multiple homeostatic functions. Although the metabotropic glutamate receptors have been shown to be coupled to TRPC channel activation in cortical and sub-cortical brain regions, in the hypothalamus multiple amine and peptidergic G protein-coupled receptors (GPCRs) and growth factor/cytokine receptors are linked to activation of TRPC channels that are vital for reproduction, temperature regulation, arousal and energy homeostasis. In addition to the neurotransmitters, circulating hormones like insulin and leptin through their cognate receptors activate TRPC channels in POMC neurons. Many of the post-synaptic effects of the neurotransmitters and hormones are regulated in different physiological states by expression of TRPC channels in the post-synaptic neurons. Therefore, TRPC channels are key targets not only for neurotransmitters but circulating hormones in their vital role to control multiple hypothalamic functions, which is the focus of this review.

KW - 17β-estradiol

KW - GnRH

KW - Insulin

KW - Kisspeptin

KW - Leptin

KW - Neurokinin B

KW - Orexin

KW - POMC

KW - TRPC channels

UR - http://www.scopus.com/inward/record.url?scp=85048294113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048294113&partnerID=8YFLogxK

U2 - 10.1016/j.yfrne.2018.05.004

DO - 10.1016/j.yfrne.2018.05.004

M3 - Article

C2 - 29859883

AN - SCOPUS:85048294113

JO - Frontiers in Neuroendocrinology

JF - Frontiers in Neuroendocrinology

SN - 0091-3022

ER -