Tropical spastic paraparesis in the seychelles islands: A clinical and case-control neuroepidemiologic study

G. C. Román, P. S. Spencer, B. S. Schoenberg, J. Hugon, A. Ludolph, P. Rodgers-Johnson, B. O. Osuntokun, C. F. Shamlaye

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We confirmed the occurrence of endemic tropical spastic paraparesis (TSP) in the Seychelles. Most patients (14/21) were low-income black women. Mean age at onset was 42.8 years (range, 20 to 65). In 62%, onset and progression were slow. Complete paralysis developed in 8/21 (38%) after an evolution of 2 to 15 years. All patients had bilateral pyramidal signs. Loss of vibratory perception occurred in 6/21 (28%). A case-control study of putative risk factors failed to show significant differences. The clinical and epidemiologic features of TSP in the Seychelles appear to be similar to those described in other tropical countries.

Original languageEnglish (US)
Pages (from-to)1323-1328
Number of pages6
JournalNeurology
Volume37
Issue number8
DOIs
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Clinical Neurology

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    Román, G. C., Spencer, P. S., Schoenberg, B. S., Hugon, J., Ludolph, A., Rodgers-Johnson, P., Osuntokun, B. O., & Shamlaye, C. F. (1987). Tropical spastic paraparesis in the seychelles islands: A clinical and case-control neuroepidemiologic study. Neurology, 37(8), 1323-1328. https://doi.org/10.1212/wnl.37.8.1323