Tropical Spastic Paraparesis: HTLV-I Antibodies in Patients from the Seychelles

Gustavo C. Román, Peter S. Spencer, Bruce S. Schoenberg, David Madden, John Sever, Jacques Hugon, Albert Ludolph

Research output: Contribution to journalLetterpeer-review

21 Scopus citations


To the Editor: HTLV-I-associated myelopathies have been reported in Japan1 and the Caribbean basin.2,3 We studied HTLV-I antibodies in serum samples from patients with tropical spastic paraparesis who were from the Seychelles Islands; we used the Bioteck enzyme-linked immunosorbent assay and an indirect fluorescent antibody test, together with HTLV-I antigen grown in HUT 102 cells. Of 20 patients with tropical spastic paraparesis diagnosed by strict criteria, 17 (85 percent) were positive for HTLV-I antibodies. Nine neurologically normal controls and five patients with other neurologic diseases were negative for HTLV-I antibodies. HTLV-I antibodies were found in one patient in the control…, No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Tropical Spastic Paraparesis: HTLV-I Antibodies in Patients from the Seychelles'. Together they form a unique fingerprint.

Cite this