Tropical spastic paraparesis

A neuroepidemiological study in Colombia

G. C. Roman, L. N. Roman, Peter Spencer, B. S. Schoenberg

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifty confirmed cases were identified (29 men, 21 women) with an estimated prevalence ratio of 98 cases per 100,000 population. Patients with identified cases ranged in age from 24 to 75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could be elicited. Ankle reflexes and vibratory sensation of the feet were decreased. Intellectual function, coordination, and cranial nerves remained normal. TSP is a slowly progressive disorder but so far there have been no deaths from it. Forty cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occurred in 74% of confirmed cases. No likely etiological neurotoxic or nutritional factors were identified. TSP also has been described in India, Africa, the Seychelles, and Jamaica.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalAnnals of Neurology
Volume17
Issue number4
StatePublished - 1985
Externally publishedYes

Fingerprint

Tropical Spastic Paraparesis
Colombia
Foot
Leg
Seychelles
Yaws
Jamaica
Abnormal Reflexes
Muscle Spasticity
Cranial Nerves
Social Conditions
Erectile Dysfunction
Gait
Occupations
Ankle
Reflex
India
Urinary Bladder
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Roman, G. C., Roman, L. N., Spencer, P., & Schoenberg, B. S. (1985). Tropical spastic paraparesis: A neuroepidemiological study in Colombia. Annals of Neurology, 17(4), 361-365.

Tropical spastic paraparesis : A neuroepidemiological study in Colombia. / Roman, G. C.; Roman, L. N.; Spencer, Peter; Schoenberg, B. S.

In: Annals of Neurology, Vol. 17, No. 4, 1985, p. 361-365.

Research output: Contribution to journalArticle

Roman, GC, Roman, LN, Spencer, P & Schoenberg, BS 1985, 'Tropical spastic paraparesis: A neuroepidemiological study in Colombia', Annals of Neurology, vol. 17, no. 4, pp. 361-365.
Roman, G. C. ; Roman, L. N. ; Spencer, Peter ; Schoenberg, B. S. / Tropical spastic paraparesis : A neuroepidemiological study in Colombia. In: Annals of Neurology. 1985 ; Vol. 17, No. 4. pp. 361-365.
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