Trophoblast cells in first trimester decidual veins: a mechanism of normal placentation?

C. Craven, Terry Morgan, K. Ward

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: In normal pieguaun, svncvtioirophoblasts (SCTB) are found in uterine venous blood and circulate to tin1 lungs. The- function ot these SCTB is unknown, hm presumably they gain access to the- matei ual circulation through decidual veins. This smd\ was undertaken to evaluate the presence of'S(]TB in first trimester decidnal veins. STUDY DESIGN: Decidua from 17 elective abortions (H-li> week) wenstained with antibodies to cuokeratin, u- smooth muscle antigen, Factoi \ 111 and human placental laetogen (ÜAKO immunologie reagents), and examined using liglit microscop\. RESULTS: All 17 cases showed SCTB in decidual veins. Venous SCTB were present in decidua a distance 1 cm awa\ from the placental bed. No evidence of direct imasion ol SCTB into decidual stroma was seen. In 17/17, SCTB in veins were entrapped in ( oagulum. In 4 ' 1 7 of specimens', placental viiu weie also seen in the veins, distant from the placental bed and from the shell ol extravillous SCTB. CONCLUSION: SCTB was present in decidual veins but did not imade into sunounding siioma. We speculate that SCTB entrapped in venous cloi max have a paracrine etfect enhancing locali/ed tiophobbstic modification of endomc-irium. Furthermoie. Placental giouih may occur by villous extension inio decidual veins.

Original languageEnglish (US)
JournalActa Diabetologica Latina
Volume176
Issue number1 PART II
StatePublished - 1997
Externally publishedYes

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Placentation
Trophoblasts
First Pregnancy Trimester
Veins
Decidua
Sodium Dodecyl Sulfate
Smooth Muscle
Antigens
Lung
Antibodies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Trophoblast cells in first trimester decidual veins : a mechanism of normal placentation? / Craven, C.; Morgan, Terry; Ward, K.

In: Acta Diabetologica Latina, Vol. 176, No. 1 PART II, 1997.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: In normal pieguaun, svncvtioirophoblasts (SCTB) are found in uterine venous blood and circulate to tin1 lungs. The- function ot these SCTB is unknown, hm presumably they gain access to the- matei ual circulation through decidual veins. This smd\ was undertaken to evaluate the presence of'S(]TB in first trimester decidnal veins. STUDY DESIGN: Decidua from 17 elective abortions (H-li> week) wenstained with antibodies to cuokeratin, u- smooth muscle antigen, Factoi \ 111 and human placental laetogen ({\"U}AKO immunologie reagents), and examined using liglit microscop\. RESULTS: All 17 cases showed SCTB in decidual veins. Venous SCTB were present in decidua a distance 1 cm awa\ from the placental bed. No evidence of direct imasion ol SCTB into decidual stroma was seen. In 17/17, SCTB in veins were entrapped in ( oagulum. In 4 ' 1 7 of specimens', placental viiu weie also seen in the veins, distant from the placental bed and from the shell ol extravillous SCTB. CONCLUSION: SCTB was present in decidual veins but did not imade into sunounding siioma. We speculate that SCTB entrapped in venous cloi max have a paracrine etfect enhancing locali/ed tiophobbstic modification of endomc-irium. Furthermoie. Placental giouih may occur by villous extension inio decidual veins.",
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N2 - OBJECTIVE: In normal pieguaun, svncvtioirophoblasts (SCTB) are found in uterine venous blood and circulate to tin1 lungs. The- function ot these SCTB is unknown, hm presumably they gain access to the- matei ual circulation through decidual veins. This smd\ was undertaken to evaluate the presence of'S(]TB in first trimester decidnal veins. STUDY DESIGN: Decidua from 17 elective abortions (H-li> week) wenstained with antibodies to cuokeratin, u- smooth muscle antigen, Factoi \ 111 and human placental laetogen (ÜAKO immunologie reagents), and examined using liglit microscop\. RESULTS: All 17 cases showed SCTB in decidual veins. Venous SCTB were present in decidua a distance 1 cm awa\ from the placental bed. No evidence of direct imasion ol SCTB into decidual stroma was seen. In 17/17, SCTB in veins were entrapped in ( oagulum. In 4 ' 1 7 of specimens', placental viiu weie also seen in the veins, distant from the placental bed and from the shell ol extravillous SCTB. CONCLUSION: SCTB was present in decidual veins but did not imade into sunounding siioma. We speculate that SCTB entrapped in venous cloi max have a paracrine etfect enhancing locali/ed tiophobbstic modification of endomc-irium. Furthermoie. Placental giouih may occur by villous extension inio decidual veins.

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