Trisomy 12 is a consistent chromosomal aberration in benign overian tumors

Tanja Pejovic, S. Heim, N. Mandahl, B. Elmfors, U. M. Floderus, S. Furgyik, G. Helm, H. Willen, F. Mitelman

Research output: Contribution to journalArticle

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Abstract

Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had - X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalGenes Chromosomes and Cancer
Volume2
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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Trisomy
Chromosome Aberrations
Mucinous Cystadenoma
Neoplasms
Adenofibroma
Serous Cystadenoma
Fibroma
Cytogenetics
Ovarian Neoplasms
Clone Cells

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Pejovic, T., Heim, S., Mandahl, N., Elmfors, B., Floderus, U. M., Furgyik, S., ... Mitelman, F. (1990). Trisomy 12 is a consistent chromosomal aberration in benign overian tumors. Genes Chromosomes and Cancer, 2(1), 48-52. https://doi.org/10.1002/gcc.2870020109

Trisomy 12 is a consistent chromosomal aberration in benign overian tumors. / Pejovic, Tanja; Heim, S.; Mandahl, N.; Elmfors, B.; Floderus, U. M.; Furgyik, S.; Helm, G.; Willen, H.; Mitelman, F.

In: Genes Chromosomes and Cancer, Vol. 2, No. 1, 1990, p. 48-52.

Research output: Contribution to journalArticle

Pejovic, T, Heim, S, Mandahl, N, Elmfors, B, Floderus, UM, Furgyik, S, Helm, G, Willen, H & Mitelman, F 1990, 'Trisomy 12 is a consistent chromosomal aberration in benign overian tumors', Genes Chromosomes and Cancer, vol. 2, no. 1, pp. 48-52. https://doi.org/10.1002/gcc.2870020109
Pejovic, Tanja ; Heim, S. ; Mandahl, N. ; Elmfors, B. ; Floderus, U. M. ; Furgyik, S. ; Helm, G. ; Willen, H. ; Mitelman, F. / Trisomy 12 is a consistent chromosomal aberration in benign overian tumors. In: Genes Chromosomes and Cancer. 1990 ; Vol. 2, No. 1. pp. 48-52.
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AU - Heim, S.

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AU - Furgyik, S.

AU - Helm, G.

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