TY - JOUR
T1 - Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors
AU - Pejovic, Tanja
AU - Heim, Sverre
AU - Mandahl, Nils
AU - Elmfors, Bengt
AU - Flodérus, Ulla‐Maria ‐M
AU - Furgyik, Stefan
AU - Helm, Góran
AU - Willén, Helena
AU - Mitelman, Felix
PY - 1990/5
Y1 - 1990/5
N2 - Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had –X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.
AB - Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had –X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.
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U2 - 10.1002/gcc.2870020109
DO - 10.1002/gcc.2870020109
M3 - Article
C2 - 2177641
AN - SCOPUS:0025142691
SN - 1045-2257
VL - 2
SP - 48
EP - 52
JO - Genes, Chromosomes and Cancer
JF - Genes, Chromosomes and Cancer
IS - 1
ER -