TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer

Lalit R. Patel, Michelle C. Barton

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations

Abstract

Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24’s bromodomain as a new therapeutic avenue.

Original languageEnglish (US)
Pages (from-to)776-778
Number of pages3
JournalCancer Cell
Volume29
Issue number6
DOIs
StatePublished - Jun 13 2016
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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