TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer

Lalit R. Patel; Michelle C. Barton

doi:10.1016/j.ccell.2016.05.014

TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer

Lalit R. Patel, Michelle C. Barton

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24’s bromodomain as a new therapeutic avenue.

Original language	English (US)
Pages (from-to)	776-778
Number of pages	3
Journal	Cancer Cell
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2016.05.014
State	Published - Jun 13 2016
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

Access to Document

10.1016/j.ccell.2016.05.014

Cite this

@article{74349072b4f3460da299bd9c1ae02a70,

title = "TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer",

abstract = "Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24{\textquoteright}s bromodomain as a new therapeutic avenue.",

author = "Patel, {Lalit R.} and Barton, {Michelle C.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = jun,

day = "13",

doi = "10.1016/j.ccell.2016.05.014",

language = "English (US)",

volume = "29",

pages = "776--778",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer

AU - Patel, Lalit R.

AU - Barton, Michelle C.

PY - 2016/6/13

Y1 - 2016/6/13

N2 - Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24’s bromodomain as a new therapeutic avenue.

AB - Prostate cancer is lethal when tumors evolve to activate androgen receptor signaling, which circumvents ligand-deprivation therapy. In this issue of Cancer Cell, Groner et al. show that histone reader and transcription co-regulator TRIM24 occupies a central role in this evolution, nominating inhibitors of TRIM24’s bromodomain as a new therapeutic avenue.

UR - http://www.scopus.com/inward/record.url?scp=84979530004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979530004&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2016.05.014

DO - 10.1016/j.ccell.2016.05.014

M3 - Short survey

C2 - 27300431

AN - SCOPUS:84979530004

SN - 1535-6108

VL - 29

SP - 776

EP - 778

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this